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Impact of Non-Motor Symptoms on Quality of Life in Patients with Early-Onset Parkinson’s Disease

Published online by Cambridge University Press:  05 January 2024

Ameya Patwardhan Open the ORCID record for Ameya Patwardhan [Opens in a new window] ,
Nitish Kamble ,
Amitabh Bhattacharya Open the ORCID record for Amitabh Bhattacharya [Opens in a new window] ,
Vikram Holla ,
Ravi Yadav Open the ORCID record for Ravi Yadav [Opens in a new window]  and
Pramod Kumar Pal Open the ORCID record for Pramod Kumar Pal [Opens in a new window]
Ameya Patwardhan
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
Nitish Kamble
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
Amitabh Bhattacharya
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
Vikram Holla
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
Ravi Yadav
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
Pramod Kumar Pal*
Affiliation:
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India
*
Corresponding author: P. K. Pal; Email: [email protected]
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Abstract:

Background:

Early-onset Parkinson’s disease (EOPD) refers to patients with Parkinson’s disease (PD) whose age at disease onset is less than 50 years. Literature on the non-motor symptoms (NMS) in these patients is very limited in the Indian context. We aimed to study the NMS in patients with EOPD and its impact on the quality of life (QoL).

Methods:

We included 124 patients with EOPD with a mean age at disease onset between 21 and 45 years and 60 healthy controls (HC). NMS were assessed using validated scales, and the QoL domains were evaluated using the PD QoL–39 scale (PDQ-39).

Results:

The mean age at disease onset in EOPD patients was 37.33 ± 6.36 years. Majority of the patients were male (66.12%). The average disease duration was 6.62 ± 5.3 years. EOPD patients exhibited a significantly higher number of NMS per patient (7.97 ± 4.69) compared to HC (1.3 ± 1.39; p < 0.001). The most common NMS reported were urinary dysfunction, body pain, poor sleep quality, constipation, anxiety, depression, cognitive impairment, and REM sleep behavior disorder. The total NMS burden correlated with the QoL measures. Distinctive patterns of QoL subdomain involvement were identified, with sleep/fatigue, mood/cognition, and urinary dysfunction independently influencing QoL metrics.

Conclusions:

Our study provides valuable insights into the NMS profile and its impact on QoL in patients with EOPD, addressing an important knowledge gap in the Indian context. By understanding the specific NMS and their influence on QoL, healthcare professionals can develop targeted interventions to address these symptoms and improve the overall QoL.

Résumé:

RÉSUMÉ:Contexte :

On entend par maladie de Parkinson précoce (MPP) une maladie dont les symptômes apparaissent avant l’âge de 50 ans. La documentation sur les symptômes non moteurs (SNM) de ce type de maladie est maigre en Inde. Aussi l’étude visait-elle à examiner les SNM chez les patients atteints de la MPP et leurs répercussions sur la qualité de vie (QV).

Méthode :

Ont participé à l’étude 124 patients atteints de la MPP chez qui les premiers symptômes sont apparus en moyenne entre l’âge de 21 ans et de 45 ans, ainsi que 60 témoins en bonne santé (TBS). Les SNM ont été évalués à l’aide d’échelles validée, et les domaines de la QV, à l’aide de l’échelle d’évaluation de la qualité de vie à 39 questions, dans la maladie de Parkinson, la PDQ-39.

Résultats :

L’âge moyen d’apparition de la MPP était de 37,33 ± 6,36 ans, et la durée moyenne de la maladie s’élevait à 6,62 ± 5,3 ans. La majorité des personnes touchées était des hommes (66,12 %). Les sujets atteints de la MPP présentaient un nombre significativement plus élevé de SNM par patient (7,97 ± 4,69) que les TBS (1,3 ± 1,39; p < 0,001). Les SNM déclarés le plus souvent étaient des troubles urinaires, des douleurs corporelles, une mauvaise qualité de sommeil, la constipation, l’anxiété, la dépression, des troubles cognitifs et des troubles de comportement du sommeil durant la phase de mouvements oculaires rapides. Une corrélation a été établie entre le fardeau total des SNM et les mesures de la QV. Des types particuliers d’atteinte à la QV dans certains sous-domaines, soit le sommeil et la fatigue, l’humeur et la cognition et les troubles urinaires, influant de manière indépendante les mesures de la QV, se sont dégagés de l’étude.

Conclusion :

L’étude a permis de dresser un tableau valable des SNM et de leurs répercussions sur la QV chez les patients atteints de la MPP, ce qui comble une lacune importante en matière de connaissances en Inde. En ayant une meilleure compréhension de ces SNM particuliers et de leur incidence sur la QV, les professionnels de la santé peuvent élaborer des interventions ciblées dans le but d’atténuer ces symptômes et d’améliorer la QV en général.

Keywords

Early onset Parkinson’s diseaseNon-motor symptomsParkinson’s diseaseQuality of life
Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 51 , Issue 5 , September 2024 , pp. 650 - 659
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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