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Immunohistochemistry of Ecchordosis Physaliphora and Chordoma

Published online by Cambridge University Press:  18 September 2015

R.L. Macdonald  and
J.H.N. Deck
R.L. Macdonald
Affiliation:
Division of Neuropathology, Department of Pathology, University of Toronto, Toronto General Hospital, Toronto
J.H.N. Deck*
Affiliation:
Division of Neuropathology, Department of Pathology, University of Toronto, Toronto General Hospital, Toronto
*
Department of Pathology, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON Canada M5G 2C4
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Abstract:

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Immunohistochemical stains for cytokeratins, vimentin, epithelial membrane antigen, carcinoembryonic antigen and S-100 were performed on nine ecchordoses and 10 chordomas. 100% of the ecchordoses were positive for cytokeratin, vimentin and epithelial membrane antigen. 78% were S-100 positive. 100% of the chordomas stained positively for cytokeratin, vimentin and S-100 and 90% were positive for epithelial membrane antigen. No ecchordosis or chordoma was carcinoembryonic-antigen positive. These findings are interesting for two reasons. First, the similar staining properties of chordoma and ecchordosis physaliphora support the embryologic hypothesis of their common origin from the fetal notochord. Second, they indicate that when an ecchordosis causes symptoms prompting surgical resection, differentiation of the lesion from chordoma with routine immunohistochemistry would not be helpful.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 420 - 423
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

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