Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-27T06:47:00.360Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunohistochemical Study of Foci of Recent Cell Death in Huntington's Disease

Published online by Cambridge University Press:  18 September 2015

P. Averback
P. Averback*
Affiliation:
Department of Pathology, University of Cambridge
*
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, England CB2 1QP
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Foci of recent cell death were identified in 10 consecutive cases of Huntington's disease in the caudate nucleus and putamen. Indirect immunohistochemical staining procedures were performed on these areas and controls using fluorescein conjugated anti-globulin and peroxidase-conjugated anti-globulin. Positive results were found when human antiserum to Cytomegalovirus was used. The possibility of abnormal antigen presence within the dying neurons in this disease is discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 2 , May 1980 , pp. 87 - 88
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

Averback, P. (1979). Histopathology of acute cell death in Huntington’s chorea brain, to appear in Journal of Pathology.Google Scholar
Bruyn, G.W. (1973). Neuropathological changes in Huntington’s chorea, in Huntington’s chorea 1872–1972, ed. Barbeau, A., Chase, T.N., and Paulson, G.W., Raven Press, New York, 399.Google Scholar
Corsellis, J.A.N. (1976). Greenfield’s Neuropathology, Arnold, London, 822.Google Scholar
Lange, H., Thorner, G., Hopf, A., Schroder, K.F. (1976). Morphometry studies of the neuropathological changes in choreatic diseases. Journal of Neurological Sciences, 28, 401–420.CrossRefGoogle Scholar