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Hippocampal Stimulation of Fornical-lesioned Rats Improves Working Memory

Published online by Cambridge University Press:  18 September 2015

J. Turnbull ,
F. Jiang  and
R. Racine
J. Turnbull*
Affiliation:
Department of Medicine, McMaster University, Hamilton
F. Jiang
Affiliation:
Department of Medicine, McMaster University, Hamilton
R. Racine
Affiliation:
Department of Psychology, McMaster University, Hamilton
*
Department of Medicine, Division of Neurology, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
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Abstract:

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Intrinsic rhythmic electrical activity in the brain, such as the hippocampal theta rhythm, might serve important roles in normal cognition. Lesions to the medial septal nuclei, or to the fimbria/fornix, disrupt the hippocampal theta rhythm and lead to memory impairment. We have superimposed an artifical stimulating rhythm to the hippocampus of rats with prior lesion of the fornix, during testing in the Morris water maze. This intervention improves performance in a test of working memory, and lends support to the view that intrinsic rhythmic activity may play an important role in normal physiology, and in certain disease states.

Résumé:

RÉSUMÉ:

Il est possible que des rhythmes électriques intrinsèques au cerveau jouent un role important dans la mémoire et dans d'autres processus physiologiques. Des lésions aux noyaux septaux ou au fornix perturbent les rhythmes thêta et résultent en un déficit de mémoire. Nous avons stimulé l'hippocampe de rats dont le fornix a été sectionné, et les avons soumis à des tests de mémoire. L'intervention produit une amélioration importante de la mémoire et renforce l'idée que les rhythmes électriques intrinsèques au cerveau jouent un rôle important dans les processus physiologiques et pathologiques.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 2 , May 1994 , pp. 100 - 103
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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