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Heterogeneity in Multiple Sclerosis: Comparison of Clinical Manifestations in Relatives

Published online by Cambridge University Press:  18 September 2015

A.D. Sadovnick ,
L.L. Hashimoto  and
S.A. Hashimoto
A.D. Sadovnick*
Affiliation:
Department of Medical Genetics, University of British Columbia, Vancouver Multiple Sclerosis Clinic, University Hospital-UBC Site, University of British Columbia, Vancouver
L.L. Hashimoto
Affiliation:
Department of Medical Genetics, University of British Columbia, Vancouver
S.A. Hashimoto
Affiliation:
Multiple Sclerosis Clinic, University Hospital-UBC Site, University of British Columbia, Vancouver
*
Dept. of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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Once diagnosed to have MS, relatives of persons who have been previously diagnosed frequently ask whether their disease course will follow that of their relative(s) with MS. The present study compared the following clinical manifestations of MS among 43 index cases and 47 of their relatives, all of whom were diagnosed to have MS and regularly attended the MS Clinic in Vancouver, British Columbia: (i) age of onset of MS, (ii) clinical course, (iii) lesion site(s) and (iv) initial symptom(s) of MS. The results from the present study are preliminary because of the small size of the study group. However, these data suggest that apart from possibly age of onset between sibling pairs, the clinical manifestations of MS are not correlated among relatives who are assessed according to the same methodology. This is significant for counselling newly diagnosed relatives of longstanding MS patients.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 387 - 390
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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