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Haloperidol-Induced Dyskinesias in the Monkey

Published online by Cambridge University Press:  18 September 2015

P. Bédard ,
J. Delean ,
J. Lafleur  and
L. Larochelle
P. Bédard*
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
J. Delean
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
J. Lafleur
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
L. Larochelle
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
*
Laboratoires de Neurobiologie, Pavilion Notre-Dame, 2075 ave de Vitré, Québec, QUE., Canada G1J 5B3
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Haloperidol (0.25 mglkg i.m.) was injected daily for 6 months in six normal monkeys. Over a 24 hour period, the following symptoms could he observed: akathisia, circling, akinesia, choreoathetoid and dystonic movements, oro-facial dyskinesias and postural tremor with or without harmaline. Six months after cessation of haloperidol, harmaline-induced postural tremor could still be observed in all animals and oro-facial abnormal movements, in one monkey. The neuropathologic study of the experimental material did not disclose any alteration of the central nervous system.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 3 , August 1977 , pp. 197 - 201
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

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