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Glycosylated Hemoglobins In Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

P. Draper ,
D. Shapcott ,
M. Langlois  and
B. Lemieux
P. Draper
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
D. Shapcott
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
M. Langlois
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
B. Lemieux
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
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In a study of glycosylated hemoglobins in Friedreich's Ataxia patients and in family members, the level was found to be higher in insulin dependent diabetics than in healthy non-diabetic control subjects (p<0.01), but was similar to non-ataxic diabetic control subjects. Results for non-diabetic Friedreich's Ataxia patients and siblings were similar to those for non-diabetic control subjects while levels were slightly increased in the heterozygotes. It is concluded that in Friedreich's Ataxia patients and family members (apart from the insulin dependent diabetics), there was no hyperglycemia sufficient to be detected as an increase in glycosylated hemoglobins.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 405 - 407
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Brooks, A.P., Baird, J., and Nairn, I.M. (1979). Rate of change of hemoglobin A, in diabetic patients. British Med. J., 2, 275.CrossRefGoogle ScholarPubMed
Dods, R.F., and Bolmey, C. (1979). Glycosylated hemoglobin assay and oral glucose tolerance test compared for detection of diabetes mellitus. Clin. Chem., 25, 764–768.CrossRefGoogle ScholarPubMed
Draper, P., Shapcott, D., Larose, A., Stankova, J., Levesque, F. and Lemieux, B. (1979). Glucose tolerance and erythrocyte insulin receptors in Friedreich’s Ataxia. Can. J. Neurol. Sci., 6, 233–239.CrossRefGoogle ScholarPubMed
Gonen, G., and Rubenstein, A.H. (1978). Haemoglobin Al and diabetes mellitus. Diabetologia, 15, 1–8.CrossRefGoogle Scholar
Jones, M.B., Koler, R.D. and Jones, R.T. (1978). Microcolumn method for the determination of hemoglobin minor fractions A1a+b and A1C. Hemoglobin, 2, 53–58.CrossRefGoogle Scholar
Leslie, R.D.G., Pyke, D.A., John, P.N. and White, J.M. (1979). How quickly can hemoglobin A, increase? British Med. J., 2, 19.CrossRefGoogle Scholar
Shapcott, D., Melancon, S., Butter-Worth, R.F., Khoury, K., Collu, R., Breton, G., Geoffroy, G., Lemieux, B., and Barbeau, A. (1976). Glucose and insulin metabolism in Fried-reich’s Ataxia. Can. J. Neurol. Sci., 3, 361–364.CrossRefGoogle ScholarPubMed
Williams, M.L., and Savage, D.C.L. (1979). Glycosylated haemoglobin in children with diabetes mellitus. Arch. Dis. Child., 54, 295–298.CrossRefGoogle ScholarPubMed