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Gliomas in Families

Published online by Cambridge University Press:  18 September 2015

Y. Ikizler ,
D.J. van Meyel ,
D.A. Ramsay ,
G.L. Abdallah ,
R.M. Allaster ,
D.R. Macdonald ,
W.K. Cavenee  and
J.G. Cairncross
Y. Ikizler
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.J. van Meyel
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.A. Ramsay
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
G.L. Abdallah
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
R.M. Allaster
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
D.R. Macdonald
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
W.K. Cavenee
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
J.G. Cairncross*
Affiliation:
Departments of Oncology (Y.I., D.J.V.M., D.R.M., J.G.C.), Clinical Neurological Sciences (D.A.R., D.R.M., J.G.C.) and Pathology (D.A.R.), University of Western Ontario and London Regional Cancer Centre (G.L.A., R.M.A., D.R.M., J.G.C.), London; Ludwig Institute for Cancer Research (W.K.C.), San Diego Branch, San Diego
*
London Regional Cancer Centre, 790 Commissioners Road, East, London, Ontario, Canada N6A 4L6
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Abstract:

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This is a descriptive study of 19 families with glial tumors. Twelve were identified prospectively from 178 consecutive, unrelated adults and children with newly diagnosed gliomas seen at a regional cancer center between 01 Jan 89 and 31 Mar 91 (6.7%). There were 45 affected members (42 confirmed); 30 males, 15 females, ages 4 months-78 years (median, 44.5 years; mean, 38.9 years). Two families had four affected members, three families had three, and the others two. All confirmed tumors were supratentorial and all, save one, contained an astrocytic element. Three additional members of two families had other brain or neuroectodermal tumors. These families were not unusually cancer prone and did not appear to have neurofibromatosis, tuberous sclerosis, or colonic polyposis. There was no consistent pattern of inheritance.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 4 , November 1992 , pp. 492 - 497
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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