Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-22T06:45:24.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Frontal Lobe and Kindling in the Rat

Published online by Cambridge University Press:  18 September 2015

Michael E. Corcoran ,
Harald Urstad ,
James A. McCaughran JR.  and
Juhn A. Wada
Michael E. Corcoran*
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
Harald Urstad
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
James A. McCaughran JR.
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
Juhn A. Wada
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
*
Division of Neurological Sciences, University of British Columbia, 2075 Wesbrook Place, Vancouver V6T 1W5 Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

To test the hypothesis that the cortex participates in amygdaloid kindling in rats, bilateral aspiration lesions were made in various cortical areas in rats prior to kindling. Lesions in orbital cortex (on the dorsal lip of the rhinal sulcus) or prefrontal cortex (area 10) significantly retarded the rate of amygdaloid kindling; lesions in motor cortex, anterior cingulate cortex, or visual cortex were without effect. Detailed analysis indicated that the orbital lesioned and frontal-lesioned rats kindled relatively normally up to the second-last stage of amygdaloid kindling, in which stage they perseverated significantly longer than the controls and the other lesioned rats. These results suggest that areas of the frontal lobe participate in the elaboration and generalization of amygdaloid seizures in rats. Although retarded in rate, kindling nonetheless occurred in the lesioned rats, indicating that these cortical areas are not essential for the development of amygdaloid seizures.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 501 - 508
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

REFERENCES

Bancaud, J., Talairach, J., Morel, P.Bresson, M., Bonis, A., Geier, S., Hemon, E. and Buser, P. (1974). “Generalized” epileptic seizures elicited by electrical stimulation of the frontal lobe in man. Electroencephalography and Clinical Neurophysiology, 37, 275–282.CrossRefGoogle ScholarPubMed
Delgado, J.M.R. and Sevillano, M. (1961). Evolution of repeated hippocampal seizures in the cat. Electroencephalography and Clinical Neurophysiology, 13, 722–733.CrossRefGoogle Scholar
Domesick, V.B. (1972). Thalamic relationships of the medial cortex in the rat. Brain, Behavior and Evolution, 6, 457–483.CrossRefGoogle ScholarPubMed
Kretteck, J.E. and Price, J.L. (1974). A direct input from the amygdala to the thalamus and the cerebral cortex. Brain Research, 67, 1969–174.Google Scholar
Leonard, C.M. (1969). The prefrontal cortex of the rat. I. Cortical projections of the mediodorsal nucleus. II. Efferent connections. Brain Research, 12, 321–343.CrossRefGoogle ScholarPubMed
Leonard, C.M. (1972). The connections of the dorsomedial nuclei. Brain, Behavior and Evolution, 6, 524–541.CrossRefGoogle ScholarPubMed
McCaughran, J.A., Corcoran, M.E. and Wada, J.A. (1975). Development of kindled amygdaloid seizures in split-brain rats. Submitted for publication.Google Scholar
McIntyre, D.C. (1975). Split-brain rat: transfer and interference of kindled amygdala convulsions. Canadian Journal of Neurological Sciences, 2. This issue.CrossRefGoogle ScholarPubMed
Nauta, W.J.H. (1971). The problem of the frontal lobe: a reinterpretation. Journal of Psychiatric Research, 8, 167–187.CrossRefGoogle ScholarPubMed
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle ScholarPubMed
Skinner, J.E. (1971a). Neuroscience: a laboratory manual. Philadelphia: W. B. Saunders.Google Scholar
Skinner, J.E. (1971b). Abolition of several forms of cortical synchronization during blockade in the inferior thalamic peduncle. Electroencephalography and Clinical Neurophysiology, 31, 211–221.CrossRefGoogle ScholarPubMed
Skinner, J.E. and Lindsley, D.B. (1967). Electrophysiological and behavioral effects of blockade of the nonspecific thalamocortical system. Brain Research, 6, 95–118.CrossRefGoogle Scholar
Tanaka, A. (1972). Progressive changes of behavioral and electroencephalographic responses to daily amygdaloid stimulations in rabbits. Fukuoka Medical Journal, 63, 152–164.Google Scholar
Velasco, M., Skinner, J.E.Asaro, K.D. and Lindsley, D.B. (1968). Thalamocortical systems regulating spindle bursts and recruiting responses. I. Effect of cortical ablations. Electroencephalography and Clinical Neurophysiology, 25, 463–470.CrossRefGoogle ScholarPubMed
Wada, J.A., Osawa, T. and Mizoguchi, T. (1975). Recurrent spontaneous seizure state induced by prefrontal kindling in Sengalese baboons, Papio papio. Canadian Journal of Neurological Sciences, 2. This issue.CrossRefGoogle Scholar
Wada, J.A. and Sato, M. (1974). The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in cats: correlative electrographic and behavioral features. Neurology, 24, 565–574.CrossRefGoogle Scholar
Wada, J.A. and Sato, M. (1975). Effects of unilateral lesion in the midbrain reticular formation upon kindled amygdaloid convulsion in cats. Epilepsia, in press.CrossRefGoogle ScholarPubMed
Wake, A. and Wada, J.A. (1975). Frontal lobe and kindling in the cat. Canadian Journal of Neurological Sciences, 2. This issue.CrossRefGoogle Scholar