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Frontal Cortical Kindling in Cats

Published online by Cambridge University Press:  18 September 2015

Akira Wake  and
Juhn A. Wada
Akira Wake*
Affiliation:
Division of Neurological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada
Juhn A. Wada
Affiliation:
Division of Neurological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada
*
Health Sciences Center Hospital, 2075 Wesbrook Place, Vancouver, B.C. V6T 1W5 Canada
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Our observation of amygdaloid seizure development in cats indicated early afterdischarge propagation into basal cortical areas prior to the development of bifrontal sharp theta discharge. In view of the implied participation of the frontal lobe in amygdaloid kindling, both fractional lesioning and kindling of selective areas were performed. This paper summarizes our stimulation study involving premotor, prefrontal, mesial frontal and orbital cortices. Except for the orbital series which showed a rather strikingly similar pattern of seizure development to that of amygdaloid kindling, all areas showed significantly different features in terms of the speed of seizure development, afterdischarge propagation, fragility of developing seizure, final stage 5 seizure and post-ictal behavior pattern, interictal discharge morphology and propagation, and generalized seizure triggering threshold intensity. All these findings suggest that the frontal lobe participates in, but is not essential for, the amygdaloid seizure development. The results of ongoing fractional lesion series support such a conclusion.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 493 - 499
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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