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Friedreich's Ataxia and Oral Glucose Tolerance: I. The effect of ingested glucose on serum glucose and insulin values in homozygotes, obligate heterozygotes and potential carriers of the Friedreich's ataxia gene.

Published online by Cambridge University Press:  18 September 2015

G. Tolis ,
A. Mehta ,
E. Andermann ,
C. Harvey  and
A. Barbeau
G. Tolis
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
A. Mehta
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
E. Andermann
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
C. Harvey
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
A. Barbeau*
Affiliation:
Department of Endocrinology, the Royal Victoria Hospital, and the Department of Neurogenetics the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7
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Glucose tolerance and insulin release were evaluated in 16 families with Friedrich's ataxia. Impaired glucose tolerance differed in incidence according to the method of evaluation, but was increased in number in parents' and siblings of Friedreich's cases. Insulin output was not quantitatively different from normal, although the insulin peak was often delayed. This finding, in association with impaired glucose tolerance, suggest a defect in glucose entry into cells.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 397 - 400
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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