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The Focal Encephalopathies Associated with Mycoplasma Pneumoniae

Published online by Cambridge University Press:  18 September 2015

D. Sheth Raj*
Affiliation:
Divisions of Pediatrics and Neurology, Memorial University of Newfoundland, St. John’s, Newfoundland
J. Goulden Keith*
Affiliation:
Divisions of Pediatrics and Neurology, Memorial University of Newfoundland, St. John’s, Newfoundland
*
Dept. of Neurology and Pediatrics, West Virginia University, Morgantown, WV 26506–9180 USA
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Abstract:

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Five patients with evidence of focal encephalopathy are reported. In each case, evidence of mycoplasma pneumoniae infection was detected. No patient improved with conventional antibiotic therapy, but in three subjects, rapid and complete recovery did occur contemporaneously with the administration of high dose steroid therapy. It is suggested that focal as well as diffuse cerebral or cerebellar lesions may occur as manifestations of auto-immune disease complicating mycoplasmal infections in young people and that this illness may be designated as acute mycoplasma-associated encephalopathy.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Fisher, RS, Clark, AW, Wolinsky, JS, et al. Postinfectious leukoencephalitis complicating mycoplasma pneumoniae infections. Arch Neurol 1983; 40: 109113.Google Scholar
2.Decaux, G, Szyper, M, Ectors, M, Cornil, A, Franken, L.Central nervous system complications of mycoplasma pneumoniae. J Neurol Neurosurg Psychiatry 1980; 43: 883887.Google Scholar
3.Ropper, AH.Case Records of the Massachussetts General Hospital(35–1981). N Engl J Med 1981; 305; 507514.Google Scholar
4.Cassell, GH, Cole, BC. Mycoplasmas as agents of human disease. N Engl J Med 1981; 302: 8089.Google Scholar
5.Levine, DP, Lerner, AM.The clinical spectrum of mycoplasma pneumoniae inefections. Med Clin North Am 1978; 62: 961978.Google Scholar
1.Lerer, RJ, Kalavsky, SM.Central nervous system disease associated with mycoplasma pneumoniae infections. Pediatrics 1973; 52: 658668.Google Scholar
7.Koskiniemi, M, Rautonen, J, Lehtokoski-Lehtiniemi, E, Vaheri, A..Epidemiology of encephalitis in children – a 20-year survey. Ann Neurol 1991; 29: 492497.Google Scholar
8.Waites, KB, Duffy, LB, Baldus, K, Aronin, PA.Mycoplasmal infections of cerebrospinal fluid in children undergoing neurosurgery for hydrocephalus. Pediatr Infect Dis J 1991; 10: 952953.Google ScholarPubMed
9.Nagayama, Y, Sakurai, N, Tamai, K., et al. Isolation of mycoplasma pneumoniae from pleural fluid and/or cerebrospinal fluid: report of four cases. Scand J Infect Dis 1987; 19: 521524.Google Scholar
10.Kasahara, I, Otsubo, Y, Yanase, T, et al. Isolation and characterization of mycoplasma pneumoniae from cerebrospinal fluid of a patient with pneumonia and meningoencephalitis. J Infect Dis 1985; 152: 823825.Google Scholar
11.Abramovitz, P., Schvartzman, P., Harel, D, et al. Direct invasion of the central nervous system by mycoplasma pneumoniae: a report of two cases. J Infect Dis 1987; 155: 482487.Google Scholar
12.Sterner, G, Biberfeld, G.Central nervous system complications of mycoplasma pneumoniae infections. Scand J Infect Dis 1969; 1: 203208.Google Scholar
13.Ponka, A.Central nervous system manifestations associated with serologically-verified mycoplasma pneumoniae infection. J Infect Dis 1980; 12: 175184.Google Scholar
14.Goldschmidt, GD, Menonna, J, Fortunato, J, Dowling, P, Cook, S. Mycoplasma antibody in Guillain-Barré syndrome and other neurological disorders. Ann Neurol 1979; 7: 108112.Google Scholar
15.Urquhart, GD.Mycoplasma pneumoniae infection and neurological complications. Brit Med J 1979; 2: 1512.CrossRefGoogle ScholarPubMed
16.Rautonen, J, Koskiniemi, M, Vaheri, A. Prognostic factors in child hood acute encephalitis. Pediatr Infect Dis J 1991; 10: 441446.Google Scholar
17.Lehtokoski-Lehtiniemi, E, Koskiniemi, M. Mycoplasma pneumoniae encephalitis: a severe entity in children. Pediatr Infect Dis J 1989; 8: 651653.CrossRefGoogle ScholarPubMed
18.Walker, RWH, Gawler, J.Serial cerebral CT abnormalities in relapsing acute disseminated encephalomyelitis. J Neurol Neurosurg Psychiatry 1989: 52: 11001102.Google Scholar
19.Coleman, RJ, Brown, JS, Butler, P, Swash, M.Cerebellar syndrome with hydrocephalus due to mycoplasma pneumoniae infection. Postgrad Med J 1990; 66: 554556.CrossRefGoogle ScholarPubMed
20.Hulihan, JF, Bebin, EM, Westmoreland, BF.Bilateral periodic lateralized epileptiform discharges in mycoplasma encephalitis. Pediatr Neurol 1992; 8: 292294.CrossRefGoogle ScholarPubMed
21.Al-Mateen, M, Gibbs, M, Dietrich, R, Mitchell, WG, Menkes, JH. Encephalitis lethargica-like illness in a girl with mycoplasma infection. Neurology 1988; 38: 11551158.Google Scholar
22.Visudhiphan, P, Chiemchanya, S, Sirinavin, S.Internal carotid artery occlusion associated with mycoplasma pneumoniae infection. Pediatr Neurol 1992; 8: 237294.Google Scholar
23.Kepes, JJ.. Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients. Ann Neurol 1993; 33: 1827.Google Scholar