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Facteurs environnementaux dans l'étiologie de la maladie de Parkinson

Published online by Cambridge University Press:  18 September 2015

J. Zayed ,
S. Ducic ,
G. Campanella ,
J.C. Panisset ,
P. André ,
H. Masson  and
M. Roy
J. Zayed*
Affiliation:
Département de médicine du travail et d'hygiène du milieu, Université de Montréal
S. Ducic
Affiliation:
Département de médicine sociale et préventive, Université de Montréal
G. Campanella
Affiliation:
Département de neurologie de l'Université de Naples
J.C. Panisset
Affiliation:
Département de médicine du travail et d'hygiène du milieu, Université de Montréal
P. André
Affiliation:
Faculté de l'éducation permanente, Université de Montréal
H. Masson
Affiliation:
Hôpital Notre-Dame de Montréal
M. Roy
Affiliation:
Département de neurobiologie de l'Institut de Recherches Cliniques de Montréal
*
Département de médecine du travail et d'hygiène du milieu, Faculté de médecine, Université de Montréal, C.P. 6128, Succ. “A”, Montréal, Québec, Canada H3C 3J7
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Abstract:

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We examined the role of the environment in the development of Parkinson's disease (PD). A group of 42 parkinsonians have been compared with a group of 84 matched controls. The epidemiological study (1987-1989) covered the territory of the Community Health Department of Valleyfield, in southern Quebec (Canada). Odds ratio adjusted for age and sex were calculated for seven environmental factors. A decreased risk for PD was associated with residence in rural areas (OR: 0.31; p ≤ 0.05) and residence near industry or mining (OR: 0.15; p ≤ 0.05). An increased risk for PD seems to be associated with occupational exposure to the three metals Mn, Fe and Al (OR: 2.28; p = 0.07) especially when the duration of exposure is longer than 30 years (OR: 13.64; p ≤ 0.05). Other environmental factors not found to be associated with PD were: pesticides manipulation, farm work, industrial work and well water consumption.

Résumé:

RÉSUMÉ:

Nous avons examiné le rôle de l'environnement dans le développement de la maladie de Parkinson (MP). Un groupe de 42 parkinsoniens a été comparé à un groupe de 84 témoins appariés, dans le cadre d'une étude épidémiologique (1987-1989) menée sur le territoire du Département de Santé Communautaire de Valleyfield, au sud du Québec (Canada). Les rapports de cotes ajustés pour l'âge et le sexe ont été calculés pour sept facteurs environnementaux. La résidence à la campagne (OR: 0,31; p ≤ 0,05) et la résidence près de mines et d'industries (OR: 0,15; p ≤ 0,05) sont associés à une diminution du risque de développer la MP. L'exposition professionnelle aux trois métaux Mn-Fe-Al semble être associée à une augmentation du risque de MP (OR: 2,28; p = 0,07) principalement lorsque la durée de l'exposition dépasse 30 ans (OR: 13,64; p ≤ 0,05). Les autres facteurs environnementaux qui n'ont pas été associés à la MP sont: la manipulation de pesticides, le travail à la ferme, le travail dans l'industrie et la consommation de l'eau de puits.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 3 , August 1990 , pp. 286 - 291
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

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