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Evaluation of Brainstem Involvement in Multiple Sclerosis

Published online by Cambridge University Press:  23 September 2014

Magdalena Krbot Skorić ,
Ivan Adamec ,
Vesna Nesek Mađarić  and
Mario Habek
Magdalena Krbot Skorić
Affiliation:
University Hospital Center Zagreb, Department of Neurology, Referral Center for Demyelinating Diseases of the Central Nervous System
Ivan Adamec
Affiliation:
University Hospital Center Zagreb, Department of Neurology, Referral Center for Demyelinating Diseases of the Central Nervous System
Vesna Nesek Mađarić
Affiliation:
University Hospital Center Zagreb, Department of Neurology, Referral Center for Demyelinating Diseases of the Central Nervous System
Mario Habek*
Affiliation:
School of Medicine, University of Zagreb, Zagreb, Croatia
*
*University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Kišpatićeva 12, HR-10000 Zagreb, Croatia. Email: [email protected]
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Abstract

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Background/Aims:

The aim of the present study was to determine the optimum method to detect brainstem lesions in patients with Multiple Sclerosis (MS).

Methods:

72 patients with the diagnosis of relapsing-remitting MS were prospectively included. Brainstem functional system score (BSFS) (part of the expanded disability status scale (EDSS) evaluating brainstem symptomatology) was calculated. Magnetic resonance imaging (MRI) was performed on 1.5T and T1, T2, PD and fluid-attenuated inversion recovery (FLAIR) sequences were analyzed for presence of brainstem lesions. Auditory evoked potentials (AEP) and ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP) were performed according to the standardized protocol.

Results:

From 72 patients, 18 (25%) had clinical involvement of the brainstem. MRI showed brainstem involvement in 29 (40%) patients. Of the neurophysiological tests, AEP showed pathological result in 16 (22%) patients, oVEMP in 36 (50%) patients, cVEMP in 18 (25%) patients, and VEMP (combination of oVEMP and cVEMP) in 45 (63%) patients. VEMP detected brainstem lesions in higher percentage than clinical examination, MRI and AEP, which was statistically significant (< 0.0001, 0.012 and < 0.0001, respectively).

Conclusions:

Results of the present study have shown that VEMPs are the optimal method to detect brainstem lesions in multiple sclerosis and that they detect them significantly better than clinical examination, AEP or MRI.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 41 , Issue 3 , May 2014 , pp. 346 - 349
Copyright
Copyright © The Canadian Journal of Neurological 2014

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