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Epidemiological Study of Ruptured Intracranial Aneurysms in the Saguenay-Lac-Saint-Jean region (Quebec, Canada)

Published online by Cambridge University Press:  18 September 2015

Jean Mathieu ,
Louis Pérusse ,
Pierre Allard ,
Claude Prévost ,
Léo Cantin ,
Jean-Marie Bouchard  and
Marc DeBraekeleer
Jean Mathieu*
Affiliation:
Unité de recherche clinique, Hôpital de Chicoutimi, Chicoutimi
Louis Pérusse
Affiliation:
IREP, Université du Québec à Chicoutimi, Chicoutimi
Pierre Allard
Affiliation:
Groupe de recherche en epidémiologie de l’Université Laval. Québec
Claude Prévost
Affiliation:
Unité de recherche clinique, Hôpital de Chicoutimi, Chicoutimi
Léo Cantin
Affiliation:
Unité de recherche clinique, Hôpital de Chicoutimi, Chicoutimi
Jean-Marie Bouchard
Affiliation:
Hôpital Entant-Jésus, Québec
Marc DeBraekeleer
Affiliation:
Unité de recherche clinique, Hôpital de Chicoutimi, Chicoutimi
*
Unité de recherche clinique. Hôpital de Chicoutimi, 305 Saint-Vallier, Chicoutimi, QC, Canada G7H 5H6
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Abstract

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Background: Using a population-based register of the Saguenay-Lac-Saint-Jean region (Quebec, Canada), the genealogical reconstruction of 533 individuals with intracranial aneurysm (IA) showed a familial aggregation (the presence of aneurysm in two or more first- to third-degree relatives) for 159 (29.8%) of them; this proportion is much higher than reported elsewhere. Objective: As part of an ongoing project to assess a genetic predisposition to intracranial aneurysms in the Saguenay-Lac-Saint-Jean population, the objective of the present study was to determine whether age-specific rates of ruptured cerebral aneurysms were higher than in other populations. Design: A retrospective study of cases of proven ruptured I As which were hospitalized during the 1973 to 1992 period was conducted. Age-adjusted rates were computed and compared to those reported in the Helsinki population. Results: We identified 412 cases of ruptured aneurysms. The age-adjusted incidence rate was 7.2/100,000/year (6.2 for men, 8.1 for women), which is similar to the incidence rates reported in other studies. Although the mean age at time of rupture was younger (46.6 years ± 13.8) than usually reported, no increase in age-specific incidence rates was detected. Conclusions: The results of this epidemiological study neither support nor reject the hypothesis of a genetic predisposition to intracranial aneurysms in the Saguenay-Lac-Saint-Jean population.

Résumé

Résumé

Étude épidémiologique sur les anévrismes intracrâniens ruptures dans la région du Saguenay-Lac-Saint-Jean (Québec, Canada). Introduction: La reconstruction généalogique de 533 individus atteints d’anévrisme intracrânien (AI), au moyen d’un registre de population de la région du Saguenay-Lac-Saint-Jean (Québec, Canada), a montré une agrégation familiale (la présence d’un anévrisme chez deux cas ou plus qui sont apparentés au premier, deuxième ou troisième degré) chez 159 d’entre eux (29.8%). Cette proportion est bien plus élevée que celle déjà rapportée. Objectif: Cette étude fait partie d’un projet dont le but est d’évaluer la prédisposition génétique aux Aïs dans la population du Saguenay-Lac-Saint-Jean (SLSJ). L’objectif était de déterminer si les taux d’anévrismes cérébraux ruptures ajustés pour l’âge étaient plus élevés que dans les autres populations. Conception: Il s’agit d’une étude rétrospective de cas prouvés d’Aïs ruptures qui ont été hospitalisés entre 1973 et 1992. Les taux ajustés pour l’âge ont été calculés et comparés à ceux rapportés pour la population d’Helsinki. Résultats: Nous avons identifié 412 cas d’anévrismes ruptures. Le taux d’incidence était de 7.2/100,000/année (6.2 pour les hommes, 8.1 pour les femmes), ce qui est semblable aux taux d’incidence rapportés dans d’autres études. Bien que l’âge moyen au moment de la rupture était plus jeune (46.6 13.8 ans) que ce qui est habituellement rapporté, nous n’avons pas noté d’augmentation dans les taux d’incidence selon l’âge. Conclusions: Les résultats de cette étude épidémiologique ne supportent ni ne rejettent l’hypothèse d’une prédisposition génétique aux anévrismes intracrâniens dans la population du SLSJ.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 23 , Issue 3 , August 1996 , pp. 184 - 188
Copyright
Copyright © Canadian Neurological Sciences Federation 1996

References

1. Tomer, JC. Epidemiology of subarachnoid hemorrhage. Semin Neurol 1984; 4: 354–369.Google Scholar
2. Sarti, C., Tuomilehto, J., Salomaa, V., et al. Epidemiology of subarachnoid hemorrhage in Finland from 1983 to. Stroke 1991; 22: 848–853.CrossRefGoogle Scholar
3. DeBraekeleer, M., Pérusse, L., Cantin, L., Bouchard, JM., Mathieu, J. Study of inbreeding and kinship of intracranial aneurysms in the Saguenay-Lac-Saint-Jean region (Quebec, Canada). Ann Hum Genet, 1996 (in press).Google Scholar
4. De Braekeleer, M. Hereditary disorders in Saguenay-Lac-Saint-Jean (Quebec, Canada). Hum Hered 1991; 41: 141–146.Google Scholar
5. De Braekeleer, M., Larochelle, J. Genetic epidemiology of hereditary tyrosinemia in Quebec and Saguenay-Lac-Saint-Jean. Am J Hum Genet 1990; 47: 302–307.Google Scholar
6. Rozen, R., De Braekeleer, M., Daigneault, J. Cystic fibrosis mutations in French Canadians: three CFTR mutations are relatively frequent in a Quebec population with an elevated incidence of cystic fibrosis. Am J Med Genet 1992; 42: 360–364.Google Scholar
7. Rothman, KJ. Modern Epidemiology. Boston: Little, Brown and Co, 1986.Google Scholar
8. Pakarinen, S. Incidence, aetiology, and prognosis of primary subarachnoid haemorrhage. Acta Neurol Scand 1967; 43: 1–128.Google ScholarPubMed
9. Sahs, N., Perret, G., Locksley, HB., et al. (eds). Intracranial Aneurysms and Subarachnoid Hemorrhage: a cooperative study. Philadelphia: JB Lippincott, 1969.Google Scholar
10. Stehbens, WE. Pathology of the Cerebral Blood Vessels. Saint Louis: C.V. Mosby, 1972.Google Scholar
11. Yoshimoto, T., Kayama, T., Kodama, N., Suzuki, J. Distribution of intracranial aneurysm. Tohoku J Exp Med 1978; 126: 125–132.Google Scholar
12. Andrews, RJ., Spiegel, PK. Intracranial aneurysms: age, sex, blood pressure, and multiplicity in an unselected series of patients. J Neurosurg 1979; 51: 27–32.Google Scholar
13. Fox, JL. Intracranial Aneurysms. New-York: Springer-Verlag, 1983.Google Scholar
14. Hishimoto, A., Ueta, K., Onbe, H., et al. Nationwide cooperative study of intracranial aneurysm surgery in Japan. Stroke 1985; 16: 48–52.CrossRefGoogle Scholar
15. Kassell, NF., Tomer, JC., Haley, EC., et al. The international cooperative study on the timing of aneurysm surgery. J Neurosurg 1990; 73: 18–36.CrossRefGoogle Scholar
16. Lozano, A., Leblanc, R. Familial intracranial aneurysms. J Neurosurg 1987; 66: 522–528.Google Scholar
17. Bonita, R., Thomson, S. Subarachnoid hemorrhage: epidemiology, diagnosis, management, and outcome. Stroke 1985; 16: 591–594.CrossRefGoogle ScholarPubMed
18. Phillips, LH., Whisnant, JP., O’Fallon, WM., Sundt, TM. The unchanging pattern of subarachnoid hemorrhage in a community. Neurology 1980; 30: 1034–1040.CrossRefGoogle ScholarPubMed
19. Ostergaard Kristensen, M. Increased incidence of bleeding intracranial aneurysms in greenlandic eskimos. Acta Neurochir 1983; 67: 37–43.CrossRefGoogle ScholarPubMed
20. Marks, PV., Hope, JK., Cluroe, AD., Furneaux, CE. Racial differences between Maori and European New Zealanders in aneurysmal subarachnoid haemorrhage. Br J Neurosurg 1993; 7: 175–181.CrossRefGoogle ScholarPubMed
21. Fogelholm, R. Subarachnoid hemorrhage in Middle-Finland: incidence, early prognosis and indications for neurosurgical treatment. Stroke 1981; 12: 296–301.CrossRefGoogle ScholarPubMed
22. Ammar, A., Al-Rajeh, S., Ibrahim, AW., Chowdhary, UM., Awada, A. Pattern of subarachnoid haemorrhage in Saudi Arabia. Acta Neurochir (Wien) 1992; 114: 16–19.CrossRefGoogle ScholarPubMed
23. Nogueira, GJ. Spontaneous subarachnoid haemorrhage and ruptured aneurysms in the Middle East. A myth revisited. Acta Neurochir (Wien) 1992; 114: 20–25.Google Scholar
24. Ohaegbulam, SC., Dujovny, M., Ausman, JI., Diaz, FG., Malik, GM. Ethnic distribution of intracranial aneurysms. Acta Neurochir (Wien) 1990; 106: 132–135.Google Scholar
25. Weir, B. Aneurysms Affecting the Nervous System. Baltimore: Williams and Wilkins, 1987.Google Scholar
26. McCormick, WF., Schmalstieg, EJ. The relationship of arterial hypertension to intracranial aneurysms. Arch Neurol 1977; 34: 285–287.Google Scholar
27. ter Berg, HW., Dippel, DW., Limburg, M., Schievink, WI., van Gijn, J. Familial intracranial aneurysms. A review. Stroke 1992; 23: 1024–1030.CrossRefGoogle ScholarPubMed
28. Norrgard, Ö, Àngquist, K-A., Fodstad, H., Forsell, A., Lindberg, M. Intracranial aneurysms and heredity. Neurosurgery 1987; 20: 236–239.Google Scholar
29. Ronkainen, A., Hernesniemi, J., Ryynanen, M. Familial subarachnoid hemorrage in East Finland, 1977–1990. Neurosurgery 1993; 33: 787–796.Google Scholar
30. Schievink, WI., Schaid, DJ., Rogers, HM., Piepgras, DG., Michels, VV. On the inheritance of intracranial aneurysms. Stroke 1994; 25: 2028–2037.Google Scholar