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Electrophysiological Studies in Five Cases of Abetalipoproteinemia

Published online by Cambridge University Press:  18 September 2015

N.J. Lowry ,
M.J. Taylor ,
W. Belknapp  and
W.J. Logan
N.J. Lowry
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto
M.J. Taylor
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto
W. Belknapp
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto
W.J. Logan
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto
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Summary

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Auditory brainstem responses (ABRs), visual and somatosensory evoked responses (VEPs and SEPs) and nerve conduction studies were conducted in 5 patients with abetaiipoproteinemia. The ABRs were normal in all cases. The VEPs were of normal amplitude but of increased latencies in two patients. The four eldest patients had delayed cortical SEPs but normal peripheral sensory nerve conduction studies. The peripheral motor conduction velocities were normal in all cases. The peripheral sensory studies showed normal velocity when a response was seen; however, the amplitude of the response was often reduced or it was absent. The electrophysiological studies reported here support a model of axonal loss of large myelinated fibres with secondary demyelination in abetaiipoproteinemia.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 1 , February 1984 , pp. 60 - 63
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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