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Electrophysiological Disorders in Multiple Sclerosis and Optic Neuritis

Published online by Cambridge University Press:  18 September 2015

E.A.C.M. Sanders ,
J.P.H. Reulen ,
L.A.H. Hogenhuis  and
E.A. van der Velde
E.A.C.M. Sanders
Affiliation:
Department of Neurology, University Hospital Leiden
J.P.H. Reulen
Affiliation:
Department of Medical Physics, Free University Amsterdam
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Abstract:

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Visual evoked response (VER), auditory brainstem evoked response (ABER), somatosensory evoked response (SSER), blink reflex and electronystagmographic (ENG) investigative methods were applied to a group of 89 patients with Multiple Sclerosis (MS) and Optic Neuritis (ON). The MS patients were classified as definite (n = 31), probable (n = 31) and possible (n = 27).

The aim of this study was to determine the diagnostic value of the five electrophysiological tests in MS. VER and ABER recordings were found to reveal the highest number of asymptomatic abnormalities (33 and 31 percent respectively). The combination of VER, ABER and ENG revealed all possible electrophysiological disorders. As these tests are completely non-invasive it is proposed, that a combination of two of these three tests is useful for the detection of a second silent lesion in patients with suspected MS showing purely spinal signs (VER, ENG, ABER) and/or a history of uncomplicated ON (ABER, ENG).

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 4 , November 1985 , pp. 308 - 313
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

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