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Efficacy of Topiramate

Published online by Cambridge University Press:  18 September 2015

J. Bruni
J. Bruni*
Affiliation:
Division of Neurology, Wellesley Central Hospital, University of Toronto, Toronto
*
The Wellesley Central Hospital, 318JB-160 Wellesley Street East, Toronto, Ontario, Canada M4Y 1J3
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Abstract:

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In controlled clinical trials, topiramate (TopamaxR) has demonstrated efficacy in refractory patients with complex partial seizures and secondarily generalized tonic-clonic seizures. Approximately 45 percent of 534 patients had a ≥ 50 percent reduction in seizure frequency. Limited open label trials have shown that topiramate has broad spectrum activity and may be effective in patients with primary generalized epilepsies. The efficacy of topiramate compares very favourably with the efficacy of other new antiepileptic drugs recently introduced.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 25 , Issue S3 , August 1998 , pp. S6 - S7
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

References

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