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Effects of Glutamate and Aspartate on Ataxic Gait Induced by 3-Acetyl Pyridine in Rats

Published online by Cambridge University Press:  18 September 2015

G. De Michele ,
F.B. Jolicoeur ,
D.B. Rondeau ,
R.F. Butterworth  and
A. Barbeau
G. De Michele
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
F.B. Jolicoeur
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
D.B. Rondeau
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
R.F. Butterworth
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Ave. West, Montreal, Québec, Canada H2W 1R7
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Summary:

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The main purpose of this study was to examine the effects of intraventricular injections of glutamate and aspartate on the walking gait of rendered ataxic by the administration of 3-acetyl pyridine. Both amino acids significantly improved the walking gait of these animals. The effects of other substances known to have a stimulatory influence on locomotor activity in rats were also investigated. Amphetamine, apomorphine and thyrotropin releasing hormone (TRH) had no effect on the ataxic gait of 3-AP treated animals. Substance P significantly improved the gait of ataxic animals, but to a lesser extent than that seen with glutamate and aspartate.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 451 - 454
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Butterworth, R.F., Hamel, E., Landreville, F. and Barbeau, A. (1978). Cerebellar ataxia produced by 3-acetyl pyridine in rat. Can. J. Neurol. Sci. 5: 1331–1333.CrossRefGoogle ScholarPubMed
Desclin, J.C. (1971). Histological evidence supporting the inferior olive as the major source of cerebellar climbing fibers. Brain Res. 77: 365–384.CrossRefGoogle Scholar
Desclin, J.C. and Escubi, J. (1974). Effects of 3-acetyl pyridine on the central nervous system of the rat. as demonstrated by silver methods. Brain Res. 77: 349–363.CrossRefGoogle Scholar
Guidotti, A., Biggio, G. and Costa, E. (1975). 3-Acetyl pyridine: a tool to inhibit the tremor and the increase of cGMPcontent in cerebellar cortex elicited by harmaline. Brain Res. 96: 201–205.CrossRefGoogle Scholar
Hicks, S.P. (1955). Pathologic effects of antimetabolites. Amer. J. Path. 31: 189–197.Google ScholarPubMed
Holmes, G. (1907). A form of familial degeneration of cerebellum. Brain 30: 466–471.CrossRefGoogle Scholar
Huxtable, R., Azari, H.I., Reisine, T., Johnson, P., Yamamura, H.I. and Barbeau, A. (1979). Regional distribution of amino acids in Friedreich’s ataxia patients. Can. J. Neurol. Sci. 6: 255–258.CrossRefGoogle Scholar
Jolicoeur, F.B., Rondeau, D.B., Hamel, E., Butterworth, R.F. and Barbeau, A. (1979). Measurement of ataxia and related neurological signs in the laboratory rat. Can. J. Neurol. Sci. 6: 209–215.CrossRefGoogle ScholarPubMed
Mcbride, W.J., Rea, M.A. and Nadi, N.S. (1978). Effects of 3-acetyl pyridine on the levels of several amino acids in different CNS regions of the rat. Ncurochcm. Res. 3: 793–801.Google Scholar
Nadi, N.S., Kantf, R.D., Mcbride, W.J. and Aprison, M.H. (1977). Effects of 3-acetyl pyridine on several putative neuro-transmitter amino acids in the cerebellum and medulla of the rat. J. Ncurochcm. 28: 661–662.CrossRefGoogle Scholar
Rea, M.A., Mcbride, W.J. and Rohde, B.H. (1980). Regional and synaptosomal levels of amino acid neurotransmitters in the 3-acetyl pyridine deafferentated rat cerebellum. J. Neurochem. 34: 1104–1106.CrossRefGoogle Scholar
Robinson, N. (1968). Chemical changes in spinal cord in Friedreich’s ataxia and motor neurone disease. J. Neurol. Neurosurg. Psychiat. 31: 330–333.CrossRefGoogle ScholarPubMed