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The Effect of Tricyclic Antidepressants on Cortex- and Amygdala-Kindled Seizures in the Rat

Published online by Cambridge University Press:  18 September 2015

R. Yacobi  and
W.M. Burnham
R. Yacobi
Affiliation:
Department of Pharmacology, University of Toronto, Toronto
W.M. Burnham*
Affiliation:
Department of Pharmacology, University of Toronto, Toronto
*
Department of Pharmacology, M.S.B., University of Toronto, Toronto, Ontario, Canada M5S 1A8
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Abstract:

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The anticonvulsant effects of amitriptyline, imipramine, nortriptyline and desipramine were tested against focal and generalized seizures, triggered from either the amygdala or the cortex in fully kindled rats. Tests were administered on a 72- or a 24-hour schedule. Significant seizure suppression was achieved with only one drug, amitriptyline, and it occurred only at toxic or near-toxic doses. The differential, low-dose suppression of amygdala-kindled seizures, reported in earlier studies, was not seen in the present experiments. It may occur only in the short-interval test paradigms used by previous experimenters.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 2 , May 1991 , pp. 132 - 136
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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