Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-27T06:15:51.457Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary Folic Acid and The Activity of Brain Cholinergic and γ-Aminobutyric Acid (GABA) Enzymes

Published online by Cambridge University Press:  18 September 2015

M.I. Botez ,
Jocelyne Bachevalier  and
G. Tunnicliff
M.I. Botez*
Affiliation:
Clinical Research Institute of Montreal and Hôtel-Dieu Hospital, Montreal, P.Q., Canada
Jocelyne Bachevalier
Affiliation:
Clinical Research Institute of Montreal and Hôtel-Dieu Hospital, Montreal, P.Q., Canada
G. Tunnicliff
Affiliation:
Clinical Research Institute of Montreal and Hôtel-Dieu Hospital, Montreal, P.Q., Canada
*
110 Pine Ave, West, Montreal, Quebec H2W 1R7, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Charles River CD male rats were randomly divided into 3 groups of five each and placed on folate deficient, folate excess, and control diets respectively. Glutamate decarboxylase GA D y-aminohutyrate aminotransferase (GABA-T), choline acetyltransferase (ChAc), and acetylcholinesterase (AChE) were assayed in the rat brains after 6 weeks of dietary treatment. Neither folate deficiency nor folate supplementation influenced the enzymes associated with GABA and acetylcholine metabolism.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 2 , May 1980 , pp. 133 - 134
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Bachevalier, J. and Botez, M.I. (1978). Avoidance behavior in folate-deficient rats. Tohoku J. Exp. Med., 126, 111–116.CrossRefGoogle ScholarPubMed
Bachevalier, J. and Botez, M.I. (1978a). Learning in rats after large doses of folic acid. Nutr. Rep. Int., 17, 457–462.Google Scholar
Botez, M.L, Peyronnard, J.M., Bachevalier, J. and Charron, L. (1978). Polyneuropathy and folate deficiency Arch. Neurol., 35, 581–584.CrossRefGoogle ScholarPubMed
Botez, M.I., Young, S.N., Bachevalier, J. and Gauthier, S.N. (1979). Folate deficiency and decreased brain 5-hydroxy-tryptamine synthesis in man and rat. Nature, 278, 182–183.CrossRefGoogle ScholarPubMed
Botez, M.I., Botez, Th., Leveille, J., Bielmann, P. and Cadotte, M. (1979). Neuropsychological correlates of folic acid deficiency: Facts and hypotheses. In: Folic Acid in Neurology, Psychiatry and Internal Medicine eds. Botez, M.I. and Reynolds, E.H.Raven Press, New York, pp. 435–461.Google Scholar
Davies, J. and Watkins, J.C. (1973). Facilitatory and direct excitatory effects of folate and folinate on single neurons of cat cerebral cortex. Biochem. Pharmacol., 22, 1167–1168.CrossRefGoogle ScholarPubMed
Gubler, C.J., Adams, B.L., Hammon, B., Yuan, E.C., Guo, S.M. and Bennion, M. (1974). Effect of thiamine deprivation and thiamine antagonists on the level of γ-aminobutyric acid and on 2-oxoglutarate metabolism in rat brain. J. Neurochem., 22, 831–836.CrossRefGoogle ScholarPubMed
Heinrich, CP., Stadler, H. and Weiser, H. (1973). The effect of thiamine deficiency on the acetylcoenzyme A and acetylcholine levels in the rat brain. J. Neurochem., 21, 1273–1281.CrossRefGoogle ScholarPubMed
Koorevar, W.C., Greyer, M.A., Knapp, S., Hsu, L.L. and Mandell, A.J. (1973). Regional distribution of 5-methyltetrahy-drofolic acid in brain. Nature, 245, 244–245.Google Scholar
Laborit, H. (1979). The role of folic acid in central nervous system physiology. In: Folic acid in Neurology, Psychiatry and Internal Medicine eds. Botez, M.I. and Reynolds, E.H.Raven Press, New York, in press.Google Scholar
Manzoor, M. and Runcie, J. (1976). Folate-responsive neuropathy: report of 10 cases. Br. Med. J., 1: 1176–1178.CrossRefGoogle ScholarPubMed
McCaman, R.E. and Hunt, J.M. (1965). Microdetermination of choline acetylase in nervous tissue. J. Neurochem., 12, 253–259.CrossRefGoogle ScholarPubMed
McCaman, M.W., Tomey, L.R. and McCaman, R.E. (1968). Radiometric assay of acetylcholinesterase activity in submicrogram amounts of tissue. Life Sciences, 1, 233–244.CrossRefGoogle Scholar
Ngo, T.T. and Tunnicliff, G. (1978). Further evidence for the existence of isozymes of brain a-aminobutyrate aminotransferase. Comp. Biochem. Physiol., 59c, 101–104.Google Scholar
Plaitakis, A.Nicklas, W.J. and Berl, S. (1978). Thiamine deficiency: Selective impairment of the cerebellar serotonergic system. Neurology, 28, 691–698.CrossRefGoogle ScholarPubMed
Reynolds, S.F. and Blass, J.P. (1975). Normal leyels of acetylcoenzyme A and acetylcholine in the brains of thiamin-deficient rats. J. Neurochem., 24, 185–186.CrossRefGoogle Scholar
Reynolds, E.H. (1976). Neurological aspects of folate and vitamin B,2 metabolism. Clin. Haematol., 5, 661–697.CrossRefGoogle Scholar
Thomson, A.D., Frank, O., Deangells, B. and Baker, H. (1972). Thiamine depletion induced by dietary folate deficiency in rats. Nutr. Rep. Int., 6, 107–110.Google Scholar
Tunicliff, G. and Ngo, T.T. (1977). Folic acid and the inhibition of brain L-glutamic decarboxylase. Experientia, 33, 67.CrossRefGoogle Scholar