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Correlation between Cerebral Blood Flow, Somatosensory Evoked Potentials, CT Scan Grade and Neurological Grade in Patients with Subarachnoid Hemorrhage

Published online by Cambridge University Press:  18 September 2015

M. Fazl ,
D.A. Houlden  and
K. Weaver
M. Fazl*
Affiliation:
Sunnybrook Health Science Centre, Division of Neurosurgery, University of Toronto
D.A. Houlden
Affiliation:
Sunnybrook Health Science Centre, Division of Neurosurgery, University of Toronto
K. Weaver
Affiliation:
Sunnybrook Health Science Centre, Division of Neurosurgery, University of Toronto
*
Division of Neurosurgery, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Ste. A-138, Toronto, Ontario, Canada M4N 3M5
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Abstract:

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Cerebral blood flow (CBF) and central conduction time (CCT) were recorded from 58 subarachnoid hemorrhage patients and from 49 age-matched controls. CBF was calculated following Xenon inhalation and CCT was determined from somatosensory evoked potentials (SSEP's) following median nerve stimulation. Each patient had a CT scan on the day of admission which was graded from I-IV. CBF, CCT and neurological grade (Hunt and Hess classification) were concomitantly recorded 1, 4, 7 and 14 days after subarachnoid hemorrhage. Mean CBF was highest in patients with neurological grades I and II (48.6 ± 12.3 and 48.1 ± 10.3 ml/lOOgm/min respectively) and lowest in patients with neurological grade IV (37.3 ± 9.6 ml/lOOgm/min). Patients in neurological grade I or II had mean CBF and CCT measurements that were significantly different from those obtained from patients in neurological grade IV (P < 0.05). Neurological grade and CT scan grade correlated with CBF (P < 0.0001) better than CCT (P = 0.015). Unexpectedly low CBF's from patients in neurological grades II and III (< 37 and < 31 ml/lOOgm/min respectively) failed to significantly prolong CCT suggesting CCT is unable to detect marginal ischemia. A significant correlation between CBF and CCT occurred only when CBF was < 30 ml/lOOgm/min (R = 0.75, P = 0.05). It appears that prolonged CCT is associated with a drop in CBF only when CBF drops below a certain threshold.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 4 , November 1991 , pp. 453 - 457
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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