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Corpus Callosum and Cingulum Tractography in Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Katie Wiltshire ,
Luis Concha ,
Myrlene Gee ,
Thomas Bouchard ,
Christian Beaulieu  and
Richard Camicioli
Katie Wiltshire
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Luis Concha
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Myrlene Gee
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Thomas Bouchard
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Christian Beaulieu
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Richard Camicioli*
Affiliation:
Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
*
E223 Glenrose Rehabilitation Hospital, 10120111th Avenue, Edmonton, Alberta, T5G 0B7, Canada.
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Abstract

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Background:

In Parkinson's disease (PD) cell loss in the substantia nigra is known to result in motor symptoms; however widespread pathological changes occur and may be associated with non-motor symptoms such as cognitive impairment. Diffusion tensor imaging is a quantitative imaging method sensitive to the micro-structure of white matter tracts.

Objective:

To measure fractional anisotropy (FA) and mean diffusivity (MD) values in the corpus callosum and cingulum pathways, defined by diffusion tensor tractography, in patients with PD, PD with dementia (PDD) and controls and to determine if these measures correlate with Mini-Mental Status Examination (MMSE) scores in parkinsonian patients.

Methods:

Patients with PD (17 Males [M], 12 Females [F]), mild PDD (5 M, 1F) and controls (8 M, 7F) underwent cognitive testing and MRI scans. The corpus callosum was divided into four regions and the cingulum into two regions bilaterally to define tracts using the program DTIstudio (Johns Hopkins University) using the fiber assignment by continuous tracking algorithm. Volumetric MRI scans were used to measure white and gray matter volumes.

Results:

Groups did not differ in age or education. There were no overall FA or MD differences between groups in either the corpus callosum or cingulum pathways. In PD subjects the MMSE score correlated with MD within the corpus callosum. These findings were independent of age, sex and total white matter volume.

Conclusions:

The data suggest that the corpus callosum or its cortical connections are associated with cognitive impairment in PD patients.

Résumé:

RÉSUMÉ:Contexte:

Dans la maladie de Parkinson, il est bien connu que laperte cellulaire dans le locus niger cause des symptömes moteurs; cependant, il se produit des changements anatomopathologiques étendus qui peuvent ètre associés à des symptömes qui ne sont pas moteurs tels une atteinte cognitive. L’imagerie en tenseur de diffusion est une méthode d’imagerie quantitative qui est sensible à la microstructure des faisceaux de la substance blanche.

Objectif:

Le but de l’étude était de mesurer l’anisotropie fractionnelle (AF) et la diffusivité moyenne (DM) dans les voies du corps calleux et du cingulum, définies par la tractographie en tenseur de diffusion, chez des patients atteints de la MP, de la MP accompagnée de démence (MPD) et chez des témoins, et d’évaluer si ces mesures son corrélées avec les scores au Mini-Mental Status Examinassions (MMSE) chez des patients parkinsoniens.

Méthodes:

Des patients atteints de la MP (17 hommes et 12 femmes), de la MPD (5 hommes et 1 femme et des témoins (8 hommes et 7 femmes) ont subi une évaluation cognitive et des scans par IRM. Le corps calleux était divisé en quatre régions et le cingulum en deux régions bilatéralement pour définir les voies au moyen du programme DTIstudio (Johns Hopkins University) utilisant l’algorithme de "tracking" de fibres continu pour l’organisation des faisceaux. Des scans IRM volumétriques ont été utilisés pour mesurer le volume de la substance blanche et de la substance grise.

Résultats:

L’àge et le niveau de scolarité des différents groupes étaient semblables. Il n y avait pas de différences de FA ou de MD entre les groupes dans les voies du corps calleux ou du cingulum. Chez les sujets atteints de la MP, les scores au MMSE étaient corrélés à la MD dans le corps calleux. Ces observations étaient indépendantes de l’äge, du sexe et du volume total de la substance blanche.

Conclusions:

Selon ces données, le corps calleux ou ses connections corticales sont associés à

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 5 , September 2010 , pp. 595 - 600
Copyright
Copyright © The Canadian Journal of Neurological 2010

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