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A Comparison of CT Contrast Enhancement and BUDR Labeling Indices in Moderately and Highly Anaplastic Astrocytomas of the Cerebral Hemispheres

Published online by Cambridge University Press:  18 September 2015

Michael W. McDermott ,
Hendrikus G.J. Krouwer ,
Akio Asai ,
Satoyuki Ito ,
Takao Hoshino  and
Michael D. Prados
Michael W. McDermott*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
Hendrikus G.J. Krouwer*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
Akio Asai*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
Satoyuki Ito*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
Takao Hoshino*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
Michael D. Prados*
Affiliation:
Department of Neurological Surgery, Division of Neuro-Oncology (M.W.M., H.G.J.K., M.D.P.) and the Brain Tumor Research Center (A.A., S.I., T.H.), School of Medicine, University of California, San Francisco, California, U.S.A
*
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
Department of Neurological Surgery, c/o The Editorial Office, 1360 Ninth Avenue, Suite 210, San Francisco, California, U.S.A., 94122
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Abstract:

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Contrast enhancement on computerized tomography (CT) scans has been used in directing therapy for presumed intracranial gliomas. However, for moderately anaplastic astrocytomas (MOAAS) and highly anaplastic astrocytomas (HAAS), it provides no information about proliferative potential. The bromodeoxyuridine (BUDR) labeling index (LI), however, indicates proliferative potential, correlating with histologic malignancy and survival. An LI < 1% is a favorable indicator; LI > 5% suggests more aggressiveness. To determine the correlation, if any, between BUDR LI and contrast enhancement, CT scans of 71 patients with cerebral hemisphere tumors labeled with BUDR were retrospectively reviewed. Among 36 MOAAS, the BUDR LI was < 1% in 77% of enhanced tumors and 61% of unenhanced tumors. Among 35 HAAS, it was < 5% in 56% of enhanced tumors and 90% of unenhanced tumors. Therefore, contrast enhancement on CT scans does not always correctly predict proliferative potential in these tumors, and biopsy and labeling studies are recommended before therapy.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 1 , February 1992 , pp. 34 - 39
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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