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Clinical Differences Between Metoclopramide- and Antipsychotic-Induced Tardive Dyskinesias

Published online by Cambridge University Press:  18 September 2015

Anthony E. Lang
Anthony E. Lang*
Affiliation:
Movement Disorders Clinic, Toronto Western Hospital, Toronto
*
Movement Disorders Clinic, Toronto Western Hospital, 25 Leonard Avenue, #101, Toronto, Ontario, Canada M5T 2R2
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Abstract:

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A patient with tardive dyskinesia dominated by pelvic thrusting movements is described. A retrospective review of the clinical features documented in patients with metoclopramide- and antipsychotic-induced tardive dyskinesias seen over a six year period demonstrated that the occurrence of pronounced pelvic thrusting and respiratory dyskinesias were significantly more common in the metoclopramide treated group. The occurrence of bucco-linguomasticatory movements, limb stereotypies or chorea, and mild truncal or abdominal rocking were not significantly different between the two groups. None of the tardive dystonia patients had metoclopramide as the causative agent. These findings will require confirmation in larger, better matched patient populations. Whether the differences relate to different pharmacologic profiles of drug action, patient populations exposed, or other factors, remains to be elucidated.

Résumé:

RÉSUMÉ:

Nous décrivons le cas d'un patient présentant des dyskinésies tardives dont l'élément principal consistait en des mouvements de projection du bassin. Une revue rétrospective des manifestations cliniques observées chez les patients présentant des dyskinésies tardives induites par le métoclopramide et les antipsychotiques et ayant consulté sur une période de six ans, a démontré que l'apparition de mouvements marqués de projection du bassin et de dyskinésies respiratoires était significativement plus fréquente dans le groupe recevant du métoclopramide. L'apparition de mouvements bucco-linguo-masticatoires, de stéréotypies ou de chorée des membres et d'un léger bercement du tronc ou de l'abdomen n'était pas significativement différente chex les deux groupes. Le métoclopramide n'était l'agent causal chez aucun des patients présentant une dystonie tardive. Ces observations demandent confirmation dans des populations de patients plus grandes et mieux appariées. Il reste à déterminer si les différences observées ont trait à des profils pharmacologiques différents de l'activé de ces médicaments, à des différences entre les populations de patients exposés ou à d'autres facteurs.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 2 , May 1990 , pp. 137 - 139
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

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