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Cellular Hypersensitivity to Basic Myelin (P2) Protein in the Guillain-Barré Syndrome

Published online by Cambridge University Press:  18 September 2015

William Sheremata ,
Susan Colby ,
Y. Karkhanis  and
Edwin H. Eylar
William Sheremata*
Affiliation:
Montreal Neurological Institute and the Department of Neurology, McGill University and the Merck Institute, Rahway, N.J
Susan Colby
Affiliation:
Montreal Neurological Institute and the Department of Neurology, McGill University and the Merck Institute, Rahway, N.J
Y. Karkhanis
Affiliation:
Montreal Neurological Institute and the Department of Neurology, McGill University and the Merck Institute, Rahway, N.J
Edwin H. Eylar
Affiliation:
Montreal Neurological Institute and the Department of Neurology, McGill University and the Merck Institute, Rahway, N.J
*
Montreal Neurological Institute, 3801 University St., Montreal, Que. H3A 2B4
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Lymphocytes of 29 subjects were assayed for MIF production in response to P2 peripheral nerve protein, crude human peripheral nerve and human central nervous system Al basic myelin protein. Seven were performed in normal control subjects, 12 in Guillain-Barré patients (GB), 5 with other polyneuropathies and 5 in patients with multiple sclerosis (MS). Only GB patients with acute illness produced MIF in response to neuritogenic P2 protein and crude human nerve. Two MS patients in the acute phase of an exacerbation and one GB patient produced MIF in Response to Al protein. The results of this study demonstrate cellular hypersensitivity to a neuritogenic constituent in peripheral nervous tissue and support the concept that this may be important in the pathogenesis of GB.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 2 , May 1975 , pp. 87 - 90
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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