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CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese

Published online by Cambridge University Press:  02 December 2014

Chao Liu ,
Guansan Wang ,
Hong Liu ,
Yue Li ,
Jin Li ,
Yongqiang Dai  and
Xueqiang Hu
Chao Liu
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Guansan Wang
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Hong Liu
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Yue Li
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Jin Li
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
Yongqiang Dai
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
Xueqiang Hu*
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
*
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, No.600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Email: [email protected]
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Abstract

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Background:

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.

Objectives:

The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.

Methods:

Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.

Results:

The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.

Conclusions:

CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 4 , July 2012 , pp. 488 - 490
Copyright
Copyright © The Canadian Journal of Neurological 2012

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