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Case Report and Ultrastructural Study of Intracranial Embryonal Carcinoma

Published online by Cambridge University Press:  18 September 2015

Gerson Ejeckam ,
Margaret G. Norman  and
Leslie P. Ivan
Gerson Ejeckam
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
Margaret G. Norman*
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
Leslie P. Ivan
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
*
Dept. Pathology, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada.
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A case of a primary intracranial embryonal carcinoma, the first with ultrastructural study, is reported. The tumor was associated with precocious puberty in a 6½-year-old female. Characteristic embryoid bodies were present. At the ultrastructural level three cell types were noted: undifferentiated, differentiated, and intermediate types. The undifferentiated showed scanty cytoplasmic organelles and numerous free polysomes, while the differentiated cells contained well-developed mitochondria, Golgi apparatus, rough endoplasmic reticulum, and some contained secretory granules. The intermediate cells possessed dilated and irregularly-shaped mitochondria but still retained large numbers of free polysomes. The authors suggest that intracranial germ cell tumors be named in conformity with germ cell tumors in other sites, and that terms such as “ectopic pinealoma” and “atypical teratoma of the pineal” be used no longer.

Type
Case Report
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 447 - 450
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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