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Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients

Published online by Cambridge University Press:  23 September 2014

Baburhan Guldiken ,
Tammam Sipahi ,
Remziye Tekinarslan ,
Levent Kabayel ,
Hulya Ozkan ,
Ayhan Unlu ,
Bilge Eren Yamasan ,
Tulay Okman-Kilic  and
Nilda Turgut
Baburhan Guldiken*
Affiliation:
Department of Neurology, Trakya University Medical Faculty
Tammam Sipahi
Affiliation:
Department of Biophysics, Trakya University Medical Faculty
Remziye Tekinarslan
Affiliation:
Department of Neurology, Security Hospital of Edirne
Levent Kabayel
Affiliation:
Department of Neurology, Security Hospital of Edirne
Hulya Ozkan
Affiliation:
Department of Neurology, Security Hospital of Edirne
Ayhan Unlu
Affiliation:
Department of Biophysics, Trakya University Medical Faculty
Bilge Eren Yamasan
Affiliation:
Department of Biophysics, Trakya University Medical Faculty
Tulay Okman-Kilic
Affiliation:
Department of Obstetrics and Obstetrics, Trakya University Medical Faculty
Nilda Turgut
Affiliation:
Department of Neurology, Namık Kemal University Medical Faculty, Edirne, Turkey
*
Trakya University Medical Faculty, Department of Neurology, Edirne 22030, Turkey. Email: [email protected]
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Abstract:

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Objective:

Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine.

Material and Methods:

One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP).

Results:

The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency.

Conclusion:

Our study did not show any association between CALCA T-692C gene polymorphism and migraine.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 5 , September 2013 , pp. 722 - 725
Copyright
Copyright © The Canadian Journal of Neurological 2013

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