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Biomarkers of Oxidative Stress in Vascular Dementia Patients

Published online by Cambridge University Press:  02 December 2014

Guang-Xia Shi ,
Cun-Zhi Liu ,
Lin-Peng Wang ,
Li-Ping Guan  and
Si-Qian Li
Guang-Xia Shi
Affiliation:
Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China
Cun-Zhi Liu*
Affiliation:
Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China
Lin-Peng Wang
Affiliation:
Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China
Li-Ping Guan
Affiliation:
Acupuncture and Moxibustion department, The First Hospital affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China
Si-Qian Li
Affiliation:
Acupuncture and Moxibustion department, The First Hospital affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China
*
Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing, 100010, China. Tel: 00861052176905; Fax: 00861052176813; E-mail: [email protected]
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Abstract

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Objective:

Little is known about the role of oxidative stress in the pathogenesis of vascular dementia (VaD). The aim of this study was to investigate the biomarkers of oxidative stress in urine, as reflected by 8-hydroxydeoxyguanosine (8-OHdG), 8-isoprostaglandin F2a (8-isoPGF2a) and nitrotyrosine (NT) levels, in a group of well characterized VaD patients and in two control groups of Vascular Not Demented (VaND) patients and healthy subjects.

Methods:

Ninety-six subjects from the Tianjin municipality in China were recruited. Forty-six patients were in the VaD group, 24 patients with VaND and 26 persons with no signs of cognitive disorder were employed as control groups. Urinary 8-OHdG and 8-isoPGF2a was performed using enzyme-linked immunosorbent assay (ELISA), and urinary NT levels were measured by chemiluminescence detection.

Results:

Significantly higher urinary 8-OHdG levels were detected in VaD patients compared to VaND patients and healthy control subjects. In contrast, urinary 8-isoPGF2a levels were significantly lower in VaD patients compared with two control groups. For NT levels, no statistically significant differences were observed among the three groups.

Conclusion:

Increased urinary 8-OHdG level was a potential marker of oxidative stress in VaD patients. Furthermore, it is also important to take into account potential confounders in order to improve the identification of changes in the status of oxidative stress as related to VaD.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 1 , January 2012 , pp. 65 - 68
Copyright
Copyright © The Canadian Journal of Neurological 2012

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