Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-05T05:42:01.009Z Has data issue: false hasContentIssue false
  • English
  • Français

Bilateral Symmetrical Brain Lesions in Tricyclic Antidepressant Overdosage

Published online by Cambridge University Press:  18 September 2015

Laila M. Sabet
Laila M. Sabet*
Affiliation:
Department of Pathology, St. Claire's Mercy Hospital, St. John's, Newfoundland
*
Health Sciences Centre, Department of Pathology, London, Canada N6A 5C1
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The cerebral pathology in a case of tricyclic antidepressant overdose by amitriptyline is described. A review of the literature of similar cases is summarized. The relation of the cerebral lesions to the development of a hypertensive episode possibly induced by amitriptyline is discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 305 - 307
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Bilgi, C, Campbell, R. (1979). Cardiovascular effects of tricyclic and tetracyclic antidepressants. Can. Fam. Physician, 25, 619–625.Google ScholarPubMed
Edwards, J. (1966). Fatal imipramine overdosage. Med. J. Aust., 1, 839–840.CrossRefGoogle ScholarPubMed
Fatteh, A., Blanke, R., Mann, G. (1968). Death from imipramine poisoning. J. Forensic Sci., 13, 124–128.Google ScholarPubMed
Greenblatt, D.J.et al (1974). Multiple complications and death following protrip-tyline overdose. JAMA, 229, 556–557.CrossRefGoogle ScholarPubMed
Haqqani, M.T., Gutteridge, D.R. (1974). Two cases of clomipramine hydrochloride (Anafranil) poisoning. Forensic Sci., 3(1), 83–87.CrossRefGoogle ScholarPubMed
Hessov, I. (1971). Hypertension duringclomi-pramine therapy. Br. Med. J., 1, 406.CrossRefGoogle ScholarPubMed
Maroguerra, A.S. (1977). Poisoning with tricyclic antidepressant drugs. Clin. Toxicol., 10(2), 149–158.CrossRefGoogle Scholar
Noble, J., Matthew, H. (1969). Acute poisoning by tricyclic antidepressants. Clin. Toxicol., 2, 403–421.CrossRefGoogle Scholar
Petit, J.M.et al (1977). Tricyclic antidepressant plasma levels and adverse effects after overdose. Clin. Pharm. Ther., 21(1), 47–51.CrossRefGoogle ScholarPubMed
Schwedenberg, T.H. (1959). Leukoen-cephalopathy following carbon monoxide asphyxia. J. Neuropath. & Experim. Neurol., 18, 597–608.CrossRefGoogle Scholar
Williams, R.B., Sherter, C. (1971). Cardiac complications of tricyclic antidepressant therapy. Ann. Intern. Med., 74, 395–398.CrossRefGoogle ScholarPubMed