Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-28T21:07:04.885Z Has data issue: false hasContentIssue false
  • English
  • Français

Autonomic Neuropathy in the Streptozotocin Diabetic Rat

Published online by Cambridge University Press:  18 September 2015

George Monckton  and
Enid Pehowich
George Monckton*
Affiliation:
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada
Enid Pehowich
Affiliation:
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada
*
9 - 101 Clinical Sciences Bldg, 11282 - 84th Avenue, Edmonton, Alberta, T6G 2G3, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

An ultrastructural study of the sympathetic ganglia, dorsal sympathetic chain, and Auerbach's plexus is described in the streptozotocin diabetic rat. The observations cover the first six weeks following induction of diabetes. Degenerative changes began to appear in the axonal plasma membranes and axoplasm of unmyelinated fibers at 24 hours and were widespread by two weeks. Axonal sprouting and regenerating axons began to appear and increase in number through the 6th week. Chromatolysis in ganglion cells in sympathetic ganglia became apparent by two weeks as did degenerative changes in axons of Auerbach's plexus. This somewhat later appearance of changes in ganglion cells and Auerbach's plexus suggested the primary changes occurred in the postganglionic fibers. The cycle of change from degeneration to regeneration in the areas examined suggests either a possible toxic effect of strepiozotocin or a combination of metabolic disturbances as a cause of this neuropathy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 2 , May 1980 , pp. 135 - 142
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Cohen, M.P. and Klein, C. (1977) Glomerulopathy in rats with streptozotocin diabetes. Journal of Experimental Medicine, 623–631.Google Scholar
Dyck, P.J. and Hopkins, A.P. (1972) Electron microscopic observations on degeneration and regeneration of unmyelinated fibres. Brain 95, 223–234.CrossRefGoogle ScholarPubMed
Eliasson, S.G. (1964) Nerve conduction changes in experimental diabetes. Journal of Clinical Investigation, 43, 2353–2358.CrossRefGoogle ScholarPubMed
Eliasson, S.G. (1969) Properties of isolated nerve fibres from alloxanized rats. Journal of Neurology, Neurosurgery and Psychiatry, 32, 525–529.CrossRefGoogle ScholarPubMed
Fukuma, M., Carpentier, J.L., Orci, L., Greene, D.A., and Winegrad, A.I. (1978) An alteration in internodal myelin membrane structure in large sciatic nerve fibers in rats with acute streptozotocin diabetes and impaired nerve conduction velocity. Diabetologia, 15, 65–72.CrossRefGoogle ScholarPubMed
Gabella, G. (1976) The Structure of the Autonomic Nervous System. Chapman & Hall London.CrossRefGoogle Scholar
Greene, D.A., Dejesus, P.V. JR., Wine-Grad, A.I. (1975) Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. Journal of Clinical Investigation, 55, 1326–1336.CrossRefGoogle ScholarPubMed
Gunnarsson, R., Berne, C, and Hell-Erstrom, C. (1974) Cytotoxic effects of streptozotocin and N. nitrosometh-ilurea on the pancreatic ? cells with special regard to the role of nicotinamide adenine dinucleo-tide. Biochemical Journal, 140 (3), 487–494.CrossRefGoogle Scholar
Jakobsen, J. (1976) Axonal dwindling in early experimental diabetes. A study of cross-sectioned nerves. Diabetologia, 12, 539–546.CrossRefGoogle ScholarPubMed
Jakobsen, J. (1979) Early and preventable changes of peripheral nerve structure and function in insulin-deficient diabetic rats. Journal of Neurology, Neurosurgery, and Psychiatry, 42, 509–518.CrossRefGoogle ScholarPubMed
Jakobsen, J., and Lundbaek, K. (1976) Neuropathy in experimental diabetes. An animal model. British Medical Journal, 2, 278–279.Google ScholarPubMed
Luft, J.H. (1961) Improvements in epoxy resin embedding methods. Journal of Cell Biology, 9, 409.CrossRefGoogle ScholarPubMed
Matthews, M.R. and Raisman, G. (1969) Ultrastructural changes in the superior cervical ganglion of the rat following constriction of efferent fibres. Journal of Physiology (London), 201, 11–13 P.Google Scholar
Miyoshi, T., and Goto, I. (1973) Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes. Electroencephalography and Clinical Neurophysiology, 35, 125–131.CrossRefGoogle ScholarPubMed
Palmano, K.P., Whiting, P.H., Hawthorne, J.N. (1977) Free and lipid myoinositol in tissues from rats with acute and less severe streptozotocin-induced diabetes. Biochemical Journal, 167, 229–235.CrossRefGoogle ScholarPubMed
Seneviratne, K.N., and Peiris, O.A. (1969) The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats. Journal of Neurology, Neurosurgery, and Psychiatry, 32, 462–469.CrossRefGoogle ScholarPubMed
Sharma, A.K., and Thomas, P.K. (1974) Peripheral nerve structure and function in experimental diabetes. Journal of the Neurological Sciences, 23, 1–15.CrossRefGoogle ScholarPubMed
Sharma, A.K., Thomas, P.K., and De Molina, A.F. (1977) Peripheral nerve fiber size in experimental diabetes. Diabetes, 26, 689–692.CrossRefGoogle ScholarPubMed
Thomas, P.K., and Sharma, A.K. (1976) Neuropathy in experimental diabetes. British Medical Journal, 2, 478.CrossRefGoogle ScholarPubMed