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Astrocytomas: Old and Newly Recognized Variants, Their Spectrum of Morphology and Antigen Expression

Published online by Cambridge University Press:  18 September 2015

John J. Kepes
John J. Kepes*
Affiliation:
Department of Pathology and Oncology, The University of Kansas, College of Health Sciences and Hospital, Kansas City, Kansas, U.S.A.
*
Dept. of Pathology and Oncology, University of Kansas Medical Center, 39th and Rainbow Blvd., Kansas City, Kansas, U.S.A. 66103
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Abstract:

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The relationship between the morphology of astrocytomas and their prognosis is complex, with the localization of the tumour, the predominant cell type and the degree of anaplasia all playing an important part in determining the patient's future. Since many astrocytomas have a diversity of patterns, small needle biopsies taken from just one or a few areas may fail to elucidate the principal features of a given tumour. In addition to the astrocytoma subtypes listed in the WHO's International Histological Classification of brain tumours, new entities have been observed in the last few years. These include lipidized forms, such as the relatively benign pleomorphic xanthoastrocytoma and the highly malignant lipidized glioblastoma. Neoplastic astrocytes are capable of forming basal laminae and of phagocytosis, and often contain alpha-1-antitrypsin, features that may lead to confusing them with histiocytes. They may be arranged in a whorled pattern imitating meningiomas, their myxoid intercellular stroma may assume the morphology of cartilage and closely packed tumour cells in “epitheloid” astrocytomas come close to imitate metastatic carcinoma. Some astrocytomas contain cells indistinguishable from those of granular cell tumours of other tissues. The presence of reactive lymphocytes in astrocytomas and reactive astrocytes in malignant lymphomas can be the source of confusion between those two kinds of neoplasms.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 2 , May 1987 , pp. 109 - 121
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

1.Olszewski, J, Baxter, D. Cytoarchitecture of the human brain stem. JB Lippincott Co, 1954.Google Scholar
2.Olszewski, J. Subcortical arteriosclerotic endephalopathy. Review of the literature on the so-called Binswanger´s disease and pre-sentation of two cases. World Neurol 1962; 3: 359–375.Google Scholar
3.Berry, K, Olszewski, J. Central pontine myelinolysis. A case report. Neurology (Minneapolis) 1963; 13: 531–537.CrossRefGoogle Scholar
4.Steele, JC, Richardson, JC, Olszewski, J. Progressive supranuclear palsy. Arch Neurol 1964; 10: 333–359.CrossRefGoogle ScholarPubMed
5.Zülch, KJ. Their biology and pathology. Translated by Olszewski J and Rothballer AB. Springer Publ Co, New York 1957.Google Scholar
6.Zülch, KJ. Histological typing of tumours of the central nervous system. World Health Organization, Geneva, 1979.Google Scholar
7.Kepes, JJ, Rubinstein, LJ, Eng, LF. Meningocerebral xathoastrocytoma.A distinctive glioma of young subjects, presumably originating from subpial astrocytes, with relatively favorable prognosis. Abstract. Vlllth International Congress of Neuropathology, Washington D.C., 1978; p. 641.Google Scholar
8.Kepes, JJ, Rubinstein, LJ, Eng, LF. Pleomorphic xanthoastrocytoma: A distinctive meningocerebral glioma in young subjects with relatively favorable prognosis: A study of 12 cases. Cancer 1979; 44: 1839–1852.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
9.Kepes, JJ, Kepes, M, Slowik, F. Fibrous xanthomas and xanthosar-comas of the meninges and the brain. Acta Neuropathol (Berl) 1973; 23: 187–199.CrossRefGoogle ScholarPubMed
10.Ramsey, H. Fine structure of the surface of the cerebral cortex of human brain. J Cell Biol 1965; 26: 323–333.CrossRefGoogle ScholarPubMed
11.Kusaka, H, Hirano, A, Bornstein, MB, et al. Basal lamina formation by astrocytes in organotypic cultures of mouse spinal cord tissue. J Neuropathol Exp Neurol 1985; 44: 295–303.CrossRefGoogle ScholarPubMed
12.Kuhajda, FP, Mendelsohn, G, Taxy, JB, Long, DM. Pleomorphic xanthoastrocytoma: Report of a case with light and electron microscopy. Ultrastruct Pathol 1981; 2: 25–32.CrossRefGoogle ScholarPubMed
13.Weldon-Linne, C, Victor, TA, Groothius, DR, et al. Pleomorphic xanthoastrocytoma: Ultrastructural and immunohistochemical study of a case with a rapidly fatal outcome after surgery. Cancer 1983; 52: 2055–2063.3.0.CO;2-W>CrossRefGoogle Scholar
14.Heyerdahl Str0m, E, Skullerud, K. Pleomorphic xanthoastrocytoma: report of 5 cases. Clin Neuropathol 1983; 2: 188–191.Google Scholar
15.Maleki, M, Robitaille, Y, Bertrand, G. Atypical xanthoastrocytoma presenting as a meningioma. Surg Neurol 1983; 20: 235–238.CrossRefGoogle ScholarPubMed
16.Sakai, H, Okada, K, Yada, K, et al. Pleomorphic xanthoastrocytoma (Kepes). Neurol Surg (Japan) 1981; 13: 1519–1524.Google Scholar
17.Jones, MC, Drut, R, Raglia, G. Pleomorphic xanthoastrocytoma: a report of two cases. Pediatr Pathol 1983; 1: 459–467.CrossRefGoogle ScholarPubMed
18.Gomez, JG, Garcia, JH, Colon, LE. A variant of cerebral glioma called pleomorphic xanthoastrocytoma: case report. Neurosur-gery 1985; 16: 703–706.CrossRefGoogle ScholarPubMed
19.Grant, JW, Gallagher, PJ. Pleomorphic xanthoastrocytoma. Immu-nohistochemical methods for differentiation from fibrous histio-cytomas with similar morphology. Am J Surg Pathol 1986; 10: 336–341.CrossRefGoogle Scholar
20.Allegranza, A, Migliavacca, F, Mariani, C. Xantoastrocitoma pleomorfo cerebromeningeo. Istocitopatologia 1980; 2: 137–141.Google Scholar
21.Palma, L, Maleci, A, Di Lorenzo, N. et al. Pleomorphic xanthoastro-cytoma with 18 year survival. Case report. J Neurosurg 1985; 63: 808–810.CrossRefGoogle ScholarPubMed
22.Kepes, JJ, Rubinstein, LJ. Malignant gliomas with heavily lipidied (foamy) tumour cells: A report of three cases with immunoper-oxidase study. Cancer 1981; 47: 2451–2459.3.0.CO;2-5>CrossRefGoogle Scholar
23.Gherardi, R, Baudrimont, M, Nguyen, JP, et al. Monstrocellular heavily lipidized malignant glioma. Acta Neuropathol (Berl) 1986; 69: 28–32.CrossRefGoogle ScholarPubMed
24.Noetzel, H, Hauptmann, A. ZurFragederldentitatdessogenannten monstrocellularen Hirnsarkoms und des Liposarkoms. Frankf Zeitschr f Pathol 1964; 73: 535–539.Google Scholar
25.Zuccarello, M, Sawaya, R, Ray, MB. Demonstration of alpha-1-proteinase inhibitor in brain tumours. J Neuropathol Exp Neurol 1986; 45: 321.CrossRefGoogle Scholar
26.Tsao, M-S, Becker, L, Finlayson, M. Giant cell astrocytoma with histiocytic infiltrate. Acta Neuropathol (Berl) 1983; 59: 75–77.CrossRefGoogle ScholarPubMed
27.Miiller, W, Dahmen, HG. Lymphocytes within glial cells (“emperi-polesis”) in a case of a granular cell tumour. Acta Neuropathol (Berl) 1978; 44: 163–165.CrossRefGoogle Scholar
28.Kusaka, H, Hirano, A, Bornstein, MB. Transformation of cells of astrocyte lineage into macrophage-like cells in organotypic cultures of mouse spinal cord tissue. J Neurol Sci 1986; 72: 77–89.CrossRefGoogle ScholarPubMed
29.Kepes, JJ, Cellular whorls in brain tumours other than meningiomas. Cancer 1976; 37: 2232–2237.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
30.Mathew, T, Moossy, J. Gliomas containing bone and cartilage. J Neuropathol Exp Neurol 1974; 33: 456–471.CrossRefGoogle Scholar
31.Siqueira, EB, Bucy, PC. Case report: Chondroma arising within a mixed glioma. J Neuropathol Exp Neurol 1966; 25: 667–673.CrossRefGoogle Scholar
32.Kepes, JJ, Rubinstein, LJ, Chang, H. The role of astrocytes in the formation ofcartilage in gliomas. AmJPathol 1984; 117: 471–483.Google ScholarPubMed
33.Manuelidis, EE, Solitare, GB. Glioblastoma multiforme. In: Pathol-ogy of the Nervous System Vol II. Chapter 154. Minckler, J, ed. McGraw-Hill New York. 1971; 2063–2066.Google Scholar
34.Kepes, JJ, Fulling, KH, Garcia, JH. The clinical significance of “adenoid” formations of neoplastic astrocytes imitating meta-static carcinomas, in gliosarcomas. Clin Neuropathol 1982; 1: 139–150.Google Scholar
35.Rubinstein, LJ, M∅rk, SJ, Kepes, JJ, et al. Squamous differentiation of epithelial-like formations in glioblastoma and gliosarcoma. J Neuropathol Exp Neurol 1986; 45: 327.CrossRefGoogle Scholar
36.Mandybur, TI, Sawaya, R, Sawaya, R, Ormsby, I. The morphology and biologic behavior of human glioblastoma growing in nude mice. Cancer 1986; 58: 1061–1069.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
37.Abrikosoff, A. Über Myome ausgehend von quergestreifter willkùrlicher Muskulatur. Virch Arch Pathol Anat 1926; 260: 215–233.Google Scholar
38.Chimelli, L, Symon, L, Symon, L, Scaravilli, F. Granular cell tumour of the fifth cranial nerve: Further evidence for Schwann cell origin. J Neuropathol Exp Neurol 1984; 43: 634–642.CrossRefGoogle ScholarPubMed
39.Vaquero, J, Leunda, G, Cabezudo, JM, et al. Granular pituicytomas of the pituitary stalk. Acta Neurochir 1981; 59: 209–215.CrossRefGoogle ScholarPubMed
40.Becker, DH, Wilson, CB. Symptomatic parasellar granular cell tumours. Neurosurgery 1981; 8: 173–180.CrossRefGoogle Scholar
41.Markesbery, WR, Duffy−, PE, Cowen, D. Granular cell tumours of the central nervous system. J Neuropathol Exp Neurol 1973; 4332: 92–109.CrossRefGoogle Scholar
42.Ule, G, Tschahargane, G, Haag, D, et al. MalignerGranularzelltumor desGrosshirnmarkes.Morphologische,cytophotometrischeund neurochemische Befunde. Acta Neuropathol (Berl) 1975; 32: 143–155.CrossRefGoogle Scholar
43.Pasquier, B, Pasquier, D, Gasnier, F, et al. Tumeur ácellules granuleuses intracerebrale primitive: Arguments en faveur de son origine astrocytaire. Une observation antatomoclinique avec revue de la literatureMalignerGranularzelltumor desGrosshirnmarkes.Morphologische,cytophotometrischeund neurochemische Befunde. Arch Anat Cytol Path 1981; 29: 215–220.Google Scholar
44.Lechevalier, B, Mandard, JC, Adam, Y, et al. Tumeur á cellules granuleuses d’un hemisphere cerebral: Interet de la recherche de la proteineacidegliofibrillaire. Rev Neurol 1982; 138: 619–629.Google Scholar
45.Dickson, DW, Suzuki, KI, Kanner, R, et al. Cerebral granular cell tumour: Immunohistochemical and electron microscopic study. J Neuropathol Exp Neurol 1986; 45: 304–314.CrossRefGoogle ScholarPubMed
46.Kornfeld, M. Granular cell glioblastoma: A malignant granular cell neoplasm of astrocytic origin. J Neuropathol Exp Neurol 1986; 45: 447–462.CrossRefGoogle ScholarPubMed
47.Takeuchi, J, Barnard, RO. Perivascular lymphocytic cuffing in astrocytomas. Acta Neuropathol (Berl) 1976; 35: 265–271.Google ScholarPubMed