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Aqueduct Gliosis Caused by Keratin and Cholesterol In a Case of Craniopharyngioma

Published online by Cambridge University Press:  18 September 2015

Dikran S. Horoupian*
Affiliation:
Departments of Pathology (Neuropathology), Neurological Surgery, Neuroradiology and the Rose F. Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York, U.S.A.
Henryk M. Wisniewski
Affiliation:
Departments of Pathology (Neuropathology), Neurological Surgery, Neuroradiology and the Rose F. Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York, U.S.A.
Robert Gamble
Affiliation:
Departments of Pathology (Neuropathology), Neurological Surgery, Neuroradiology and the Rose F. Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York, U.S.A.
Arie L. Liebeskind
Affiliation:
Departments of Pathology (Neuropathology), Neurological Surgery, Neuroradiology and the Rose F. Kennedy Center for Mental Retardation and Human Development, Albert Einstein College of Medicine, The Bronx, New York, U.S.A.
*
Dept. of Pathology, Health Science Center, 700 William Ave., Winnipeg, Canada R3E 0Z3.
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Summary

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Keratin and cholesterol particles released by a craniopharyngioma were shown to be the agents involved in the production of a foreign-body granulomatous arachnoiditis and ependymitis. Some of the particles were seen embedded in the reactive subepen-dymal glial tissue along the aqueduct of Sylvius. It was thought they were a major factor leading to the aqueduc-tal stenosis. However, we have also considered that the change in cerebro-spinal fluid hydrodynamics following the ventriculopleural shunt contributed to the occlusion of the aqueduct.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

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