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Anesthetic Barbiturates in Refractory Status Epilepticus

Published online by Cambridge University Press:  18 September 2015

G.B. Young ,
W.T. Blume ,
C.F. Bolton  and
K.G. Warren
G.B. Young*
Affiliation:
University of Saskatchewan
W.T. Blume
Affiliation:
University of Western Ontario
C.F. Bolton
Affiliation:
University of Western Ontario
K.G. Warren
Affiliation:
University of Alberta
*
University Hospital, Saskatoon, Saskatchewan S7N 0X0 Canada
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Summary:

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Two patients with previous cerebral damage and seizures and three patients with acute inflammatory cerebral lesions developed status epilepticus. They were unresponsive to standard anticonvulsants, but anesthetic barbiturates (thiopental and pentobarbital) stopped the seizures promptly.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 291 - 292
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

REFERENCES

Atkinson, R.S., Rushman, G.B. and Lee, A. (1977). Synopsis of Anesthesia, pp. 172–173. John Wright and Sons Publishers. Bristol.Google Scholar
Blennow, G., Brierley, J.B., Meldrum, B.S. and Siesjô, B.K. (1978). Epileptic brain damage: the role of systemic factors that modify cerebral energy metabolism. Brain 101: 687–700.CrossRefGoogle ScholarPubMed
Conn, A.W., Edmonds, J.F. and Barker, B.A. (1978). Near drowning in cold water: current treatment regimen. Canad. Anaesth. Soc. J. 25: 259–265.CrossRefGoogle ScholarPubMed
Demopoulous, H.B., Flammn, E.S., Seligman, M.L., Jorgensen, E. and Ranshoff, J. (1977). Antioxidant effects of barbiturates in model membranes undergoing free radical change. Acta Neurol. Scand. (Suppl) 56 (64): 152–153.Google Scholar
Dundee, J.W. and Gray, R.C. (1967). Thiopentone in status epilepticus. Br. Med. J. 1: 362.CrossRefGoogle ScholarPubMed
MacDonald, R.L. and Barber, J.L. (1979). Anticonvulsant and anesthetic barbiturates: different postsynaptic actions in cultured mamalian neurons. Neurology. 29: 432–447.CrossRefGoogle Scholar
Majewska, M.D., Strosznajder, J. and Lazarewicz, J. (1978). Effect of ischemic anoxia and barbiturate anesthesia on free radical oxidation of mitochondrial phospholipids. Brain Res. 158: 432–434.CrossRefGoogle ScholarPubMed
Marshall, L.F., Shapiro, H.M., Rauscher, R. and Kaufman, N.M. (1965). Pentobarbital therapy for intracranial hypertension in metabolic coma. Crit. Care Med. 6: 1–5.CrossRefGoogle Scholar
Meldrum, B.S., Vigouroux, R.A. and Brierley, J.B. (1973). Systemic factors and epileptic brain damage. Arch. Neurol. 29: 82–87.CrossRefGoogle ScholarPubMed
Siesjo, B.K. (1978). Brain Energy Metabolism. John Wiley and Sons Publishers, Chichester.Google ScholarPubMed