Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-26T01:01:02.141Z Has data issue: false hasContentIssue false

All is not well: The Continual Challenges of Bilirubin Encephalopathy

Published online by Cambridge University Press:  02 December 2014

Jean K. Mah
Affiliation:
Calgary, Alberta
Elaine Wirrell
Affiliation:
Calgary, Alberta
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2005

References

1. Johnson, LH, Bhutani, VK, Brown, AK. System-based approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr 2002;140:385386.Google Scholar
2. Bhutani, VK, Johnson, LH. Urgent clinical need for accurate and precise bilirubin measurements in the United States to prevent kernicterus. Clin Chem 2004;50:477480.Google Scholar
3. AlOtaibi, SF, Blaser, S, MacGregor, DL. Neurological complications of kernicterus. Can J Neurol Sci 2005;32: 311315.Google Scholar
4. Conlee, JW, Shapiro, SM, Churn, SB. Expression of the alpha and beta subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: A quantitative light microscopic analysis. Acta Neuropath (Berl) 2000;99:393401.Google Scholar
5. Rodrigues, CMP, Sola, S, Brites, D. Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons. Hepatology 2002;35:11861195.CrossRefGoogle ScholarPubMed
6. Silva, R, Mata, LR, Gulbenkian, S, et al. Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH. Biochem Biophys Res Commun 1999;265:6772.CrossRefGoogle ScholarPubMed
7. Johnson, L, Brown, AK, Bhutani, VK. BIND-A clinical score for bilirubin induced neurologic dysfunction in newborns. Pediatrics 1999;104:746747.Google Scholar
8. American Academy of Pediatrics Subcommittee on Hyper-bilirubinemia. Management of hyperbilirubinemia in the newborn infant. Pediatrics 2004;114:297316.Google Scholar