Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-28T08:46:46.161Z Has data issue: false hasContentIssue false
  • English
  • Français

Afterdischarge Thresholds and Kindling Rates in Dorsal and Ventral Hippocampus and Dentate Gyrus

Published online by Cambridge University Press:  18 September 2015

Ronald Racine ,
Patty A. Rose  and
W. M. Burnham
Ronald Racine*
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario and Department of Pharmacology, University of Toronto, Toronto, Ontario
Patty A. Rose
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario and Department of Pharmacology, University of Toronto, Toronto, Ontario
W. M. Burnham
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario and Department of Pharmacology, University of Toronto, Toronto, Ontario
*
Department of Psychology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Electrodes were implanted into dorsal hippocampus (CAI), ventral CAI, dorsal dentate gyrus or ventral dentate gyrus. Epileptiform afterdisvharge (AD) thresholds were lower in dorsal areas than in ventral areas. Dorsal areas, however, required a greater number of stimulations to develop (“kindle”) a fully generalized convulsion than did ventral areas. Thresholds and kindling rates in the dentate gyrus were intermediate between dorsal and ventral CAI, except for the ventral dentate which had higher AD thresholds than ventral CAI.

Secondary sites within the hippocampus subsequently kindled within a few stimulations following completion of kindling in the primary site, regardless of which hippocampal area served as the primary site.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 4 , November 1977 , pp. 273 - 278
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

REFERENCES

Adey, W., Sunderland, S. and Dunlop, C. (1957). The entorhinal area: electrophysiological studies of its interrelations with rhinencelphalic structures and the brainstem. Electroencephalography and Clinical Neurophysiology, 9, 309–324.CrossRefGoogle ScholarPubMed
Burnham, W. (1975). Primary and “transfer” seizure development in the kindled rat. Canadian Jounal of Neurological Science, 2, 417–428.CrossRefGoogle ScholarPubMed
Elul, R. (1964). Regional differences in the hippocampus of the cat. I. Specific discharge patterns of the dorsal and ventral hippocampus and their roles in generalized seizures. Electroencephalography and Clinical Neurophysiology, 16, 470–488.CrossRefGoogle ScholarPubMed
Elul, R. (1964). Regional differences in the hippocampus of the cat. II. Projections of the dorsal and ventral hippocampus. Electroencephalography and Clinical Neurophsiology, 16, 489.502.Google ScholarPubMed
Goddard, G., McIntyre, D., Leech, C. (1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25, 295–330.CrossRefGoogle ScholarPubMed
Nadel, L. (1968). Dorsal and ventral hippocampal lesions and behavior. Physiology and Behavior, 3, 891–900.CrossRefGoogle Scholar
Neimer, W., Goodfellow, E., Speaker, J. (1963). Neocortical relations in the cat. Electroencephalography and Clinical Neurophysiology, 15, 827–838.CrossRefGoogle Scholar
Newberry, F., Racine, R., Smith, G.K. (1975). Potentials evoked by stimulation of the hippocampus: low frequency suppression effect. Physiology and Behavior, 15. 551–559.CrossRefGoogle Scholar
Pellegrino, L, Cushman, A.A stereotaxic atlas of the rat brain. 1967. Meredith, New York.Google Scholar
Racine, R. (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle ScholarPubMed
Racine, R., Burnham, W., Gartner, J. (1973). First trial motor seizures triggered by amygdaloid stimulation in the rat. Electroencephalography and Clinical Neurophysiology, 35, 487–494.CrossRefGoogle ScholarPubMed
Racine, R. (1975). Modification of seizure activity by electrical stimulation: cortical areas. Electroencephalography and clinical Neurophysiology. 38, 1–12.CrossRefGoogle ScholarPubMed
Siegel, A., Flynn, F. (1968). Differential effects of electrical stimulation and lesions of the hippocampus and adjacent regions upon attack behaviour in cats. Brain Research, 7, 252–267.CrossRefGoogle ScholarPubMed
Siegel, A., Tassoni, J. (1971a). Differential projections from the ventral and dorsal hippocampus of the cat. Brain, Behavior and Evolution, 4, 185–200.CrossRefGoogle ScholarPubMed
Siegel, A., Tassoni, J. (1971b). Differential efferent projections of the lateral and medial spetal nuclei to the hippocampus in the cat. Brain, Behavior and Evolution, 4, 201–219.CrossRefGoogle Scholar
Stevens, R., Cowey, A. (1973). Effects of dorsal and ventral hippocampal lesions on spontaneous alternation, learned attention and probability learning in rats. Brain research, 52, 203–224.CrossRefGoogle Scholar
Zaide, J. (1974). Differences between Tryon bright and dull rats in seizure activity evoked by amygdala stimulation. Physiology and Behavior, 12, 527–534.CrossRefGoogle Scholar