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Acute Ultrastructural Changes in the Middle Cerebral Artery Due to the Injury and Ischemia of Surgical Clamping

Published online by Cambridge University Press:  18 September 2015

Ronald F. Dodson ,
Yukio Tagashira  and
Lena W-F. Chu
Ronald F. Dodson*
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and The Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas, 77025
Yukio Tagashira
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and The Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas, 77025
Lena W-F. Chu
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and The Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas, 77025
*
Department of Neurology, Baylor College of Medicine, Houston, Texas 77025
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Summary:

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Ultrastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip. The experimental model utilized has been widely applied to the study of cerebral ischemia and possibly has relevance to clamps applied to the cerebral vessels during neurosurgical treatment of patients with cerebrovascular disorders.

The earliest changes within the arterial wall were found in the smooth muscle (media) and accompanying fasciculi of nerves. Changes within the nerve bundles were sufficiently advanced following 4 hours of vascular clipping to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 1 , February 1976 , pp. 23 - 27
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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