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Alcohol Use Disorder in Patients with Chronic Migraine: A Retrospective, Observational Study

Published online by Cambridge University Press:  25 January 2024

Leon S. Moskatel Open the ORCID record for Leon S. Moskatel [Opens in a new window]  and
Niushen Zhang
Leon S. Moskatel*
Affiliation:
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA
Niushen Zhang
Affiliation:
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA
*
Corresponding author: L. S. Moskatel; Email: [email protected]
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Abstract:

Objective:

The relationship between migraine and alcohol consumption is unclear. We assessed the association between chronic migraine and alcohol use disorder(AUD), relative to chronic disease controls, and in conjunction with common comorbidities.

Methods:

We conducted a retrospective, observational study. The primary outcome was the odds ratio for AUD in patients with chronic migraine or with chronic migraine and additional comorbidities relative to controls.

Results:

A total of 3701 patients with chronic migraine, 4450 patients with low back pain, and 1780 patients with type 2 diabetes mellitus met inclusion criteria. Patients with chronic migraine had a lower risk of AUD relative to both controls of low back pain (OR 0.37; 95% CI: 0.29–0.47, p < 0.001) and type 2 diabetes mellitus (OR 0.39; 95% CI: 0.29–0.52, p < 0.001). Depression was associated with the largest OR for AUD in chronic migraine (OR 8.62; 95% CI: 4.99–14.88, p < 0.001), followed by post-traumatic stress disorder (OR 6.63; 95% CI: 4.13–10.64, p < 0.001) and anxiety (OR 3.58; 95% CI: 2.23–5.75, p < 0.001).

Conclusion:

Patients with chronic migraine had a lower odds ratio of AUD relative to controls. But in patients with chronic migraine, those with comorbid depression, anxiety, or PTSD are at higher risk of AUD. When patients establish care, comorbid factors should be assessed and for those at higher risk, AUD should be screened for at every visit.

Résumé :

RÉSUMÉ :

Troubles liés à la consommation d’alcool chez des patients souffrant de migraine chronique : une étude rétrospective et observationnelle.

Objectif :

La relation qui existe entre la migraine et la consommation d’alcool n’est pas claire. À cet égard, nous avons cherché à évaluer l’association entre la migraine chronique et les troubles liés à la consommation d’alcool (TCA) en comparaison avec des témoins atteints de maladies chroniques et en conjonction avec des comorbidités communes.

Méthodes :

Nous avons mené une étude rétrospective et observationnelle dont le principal résultat évalué était le rapport de cotes (RC) pour les TCA chez des patients souffrant de migraine chronique ou de migraine chronique et de comorbidités supplémentaires en comparaison avec des témoins.

Résultats :

Au total, 3 701 patients souffrant de migraine chronique, 4 450 patients souffrant de lombalgie et 1 780 patients atteints de diabète de type 2 ont répondu à nos critères d’inclusion. À noter que les patients souffrant de migraine chronique ont présenté un risque plus faible de TCA par rapport aux témoins atteints de lombalgie (RC 0,37 ; IC 95 % : 0,29-0,47; p < 0,001) et de diabète de type 2 (RC 0,39 ; IC 95 % : 0,29-0,52 ; p < 0,001). Ajoutons aussi que la dépression a été associée à un RC plus important pour les TCA associés à la migraine chronique (RC 8,62 ; IC 95 % : 4,99-14,88 ; p < 0,001) ; elle a été suivie par le trouble de stress post-traumatique (TSPT) (RC 6,63 ; IC 95 % : 4,13-10,64 ; p < 0,001) et l’anxiété (RC 3,58 ; IC 95 % : 2,23-5,75 ; p < 0,001).

Conclusion :

Les patients souffrant de migraine chronique ont présenté un RC des TCA inférieur à celui des témoins. Cela dit, les patients souffrant de migraine chronique ainsi que ceux qui présentent une comorbidité telle que la dépression, l’anxiété ou le TSPT ont donné à voir un risque plus élevé de souffrir de TCA. Ainsi donc, lorsque des patients commencent à recevoir des soins, ces facteurs de comorbidité devraient être évalués. De plus, pour ceux qui présentent un risque plus élevé, les TCA devraient faire l’objet d’un dépistage à chaque visite.

Keywords

Chronic migraineAlcoholAlcohol use disorderDepressionAnxietyPost-traumatic stress disorder
Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 51 , Issue 6 , November 2024 , pp. 767 - 777
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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References

Aamodt, AH, Stovner, LJ, Hagen, K, Bråthen, G, Zwart, J. Headache prevalence related to smoking and alcohol use. The head-HUNT study. Eur J Neurol. 2006;13:1233–8.CrossRefGoogle ScholarPubMed
Le, H, Tfelt-Hansen, P, Skytthe, A, Kyvik, KO, Olesen, J. Association between migraine, lifestyle and socioeconomic factors: a population-based cross-sectional study. J Headache Pain. 2011;12:157–72.CrossRefGoogle ScholarPubMed
Jette, N, Pattern, S, Williams, J, et al. Comorbidity of migraine and psychiatric disorders—a national population-based study. Headache. 2008;48:501–16.CrossRefGoogle ScholarPubMed
Onderwater, GL, Van Oosterhout, WP, Schoonman, GG, Ferrari, MD, Terwindt, GM. Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine. Eur J Neurol. 2019;26:588–95.CrossRefGoogle ScholarPubMed
Vives-Mestres, M, Casanova, A, Puig, X, Ginebra, J, Rosen, N. Alcohol as a trigger of migraine attacks in people with migraine. Results from a large prospective cohort study in english-speaking countries. Headache. 2022;62:1329–38.CrossRefGoogle ScholarPubMed
Mostofsky, E, Bertisch, SM, Vgontzas, A, et al. Prospective cohort study of daily alcoholic beverage intake as a potential trigger of headaches among adults with episodic migraine. Ann Med. 2020;52:386–92.CrossRefGoogle ScholarPubMed
Błaszczyk, B, Straburzyński, M, Więckiewicz, M, et al. Relationship between alcohol and primary headaches: a systematic review and meta-analysis. J Headache Pain. 2023;24:116.CrossRefGoogle ScholarPubMed
Peterlin, BL, Rosso, AL, Sheftell, FD, Libon, DJ, Mossey, JM, Merikangas, KR. Post-traumatic stress disorder, drug abuse and migraine: new findings from the national comorbidity survey replication (NCS-R). Cephalalgia. 2011;31:235–44.CrossRefGoogle ScholarPubMed
Castillo-Carniglia, A, Keyes, KM, Hasin, DS, Cerdá, M. Psychiatric comorbidities in alcohol use disorder. Lancet Psychiatry. 2019;6:1068–80.CrossRefGoogle ScholarPubMed
Minen, MT, De Dhaem, OB, Van Diest, AK, et al. Migraine and its psychiatric comorbidities. J Neurol Neurosurg Psychiatry. 2016;87:741–9.CrossRefGoogle ScholarPubMed
Peck, KR, Smitherman, TA, Baskin, SM. Traditional and alternative treatments for depression: implications for migraine management. Headache. 2015;55:351–5.CrossRefGoogle ScholarPubMed
Baskin, SM, Lipchik, GL, Smitherman, TA. Mood and anxiety disorders in chronic headache. Headache. 2006;46:S76–87.CrossRefGoogle ScholarPubMed
Smitherman, TA, Kolivas, ED, Bailey, JR. Panic disorder and migraine: comorbidity, mechanisms, and clinical implications. Headache. 2013;53:23–45.CrossRefGoogle ScholarPubMed
Peterlin, BL, Tietjen, G, Meng, S, et al. Post-traumatic stress disorder in episodic and chronic migraine. Headache. 2008;48:517–22.CrossRefGoogle ScholarPubMed
Brière, FN, Rohde, P, Seeley, JR, Klein, D, Lewinsohn, PM. Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiat. 2014;55:526–33.CrossRefGoogle ScholarPubMed
Wiener, CD, Moreira, FP, Zago, A, et al. Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study. Braz J Psychiatry. 2018;40:1–5. DOI: 10.1590/1516-4446-2016-2170.CrossRefGoogle ScholarPubMed
Kessler, RC, Chiu, WT, Demler, O, Merikangas, KR, Walters, EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005;62:617–27.CrossRefGoogle ScholarPubMed
McEvoy, PM, Grove, R, Slade, T. Epidemiology of anxiety disorders in the Australian general population: findings of the 2007 Australian national survey of mental health and wellbeing. Aust N Z J Psychiatry. 2011;45:957–67.CrossRefGoogle ScholarPubMed
Creamer, M, Burgess, P, McFarlane, AC. Post-traumatic stress disorder: findings from the Australian national survey of mental health and well-being. Psychol Med. 2001;31:1237–47.CrossRefGoogle ScholarPubMed
Evans, EW, Lipton, RB, Peterlin, BL, et al. Dietary in-take patterns and diet quality in a nationally representative sample of women with and without severe headache or migraine. Headache. 2015;55:550–61.CrossRefGoogle ScholarPubMed
Molarius, A, Tegelberg, A, Ohrvik, J. Socio-economic factors, lifestyle, and headache disorders – a population-based study in Sweden. Headache. 2008;48:1426–37.CrossRefGoogle ScholarPubMed
Blodgett, JC, Del Re, AC, Maisel, NC, Finney, JW. A meta-analysis of topiramate’s effects for individuals with alcohol use disorders. Alcohol Clin Exp Res. 2014;38:1481–8.CrossRefGoogle ScholarPubMed
Kranzler, HR, Feinn, R, Morris, P, Hartwell, EE. A meta-analysis of the efficacy of gabapentin for treating alcohol use disorder. Addiction. 2019;114:1547–55.CrossRefGoogle ScholarPubMed
Torrens, M, Fonseca, F, Mateu, G, Farré, M. Efficacy of antidepressants in substance use disorders with and without comorbid depression: a systematic review and meta-analysis. Drug Alcohol Depen. 2005;78:1–22.CrossRefGoogle ScholarPubMed
Mulvaney-Day, N, Marshall, T, Downey Piscopo, K, et al. Screening for behavioral health conditions in primary care settings: a systematic review of the literature. J Gen Intern Med. 2018;33:335–46.CrossRefGoogle ScholarPubMed
Alcohol Use Disorder. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.Google Scholar
Dueland, AN. Headache and alcohol. Headache. 2015;55:1045–9.CrossRefGoogle ScholarPubMed
Hoffmann, NG, Kopak, AM. How well do the DSM-5 alcohol use disorder designations map to the ICD-10 disorders? Alcohol Clin Exp Res. 2015;39:697–701.CrossRefGoogle Scholar