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5-Fluorouracil Induced Hyperammonemic Encephalophathy: Etiopathologic Correlation

Published online by Cambridge University Press:  02 December 2014

Martínez-Lapiscina EH
Affiliation:
Complejo Hospitalario de Navarra Pamplona, Spain Email: [email protected]
Erro ME
Affiliation:
Complejo Hospitalario de Navarra Pamplona, Spain Email: [email protected]
Cabada T
Affiliation:
Complejo Hospitalario de Navarra Pamplona, Spain Email: [email protected]
Tuñón T
Affiliation:
Complejo Hospitalario de Navarra Pamplona, Spain Email: [email protected]
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Abstract

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Type
Letters to the Editor
Copyright
Copyright © The Canadian Journal of Neurological 2012

References

1.Yeh, KH, Cheng, AL.High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy. Br J Cancer. 1997;75(3):4645.CrossRefGoogle ScholarPubMed
2.Nott, L, Price, TJ, Pittman, K, Patterson, K, Fletcher, J.Hyperammonemia encephalopathy: an important cause of neurological deterioration following chemotherapy. Leuk Lymphoma. 2007;48(9):170211.CrossRefGoogle ScholarPubMed
3.Koenig, H, Patel, A.Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol. 1970;23(2):15560.CrossRefGoogle ScholarPubMed
4.Kim, SR, Park, CH, Park, S, Park, JO, Lee, J, Lee, SY.Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity. Chemotherapy. 2010;56(4):3137.CrossRefGoogle ScholarPubMed
5.Takanashi, J, Barkovich, AJ, Cheng, SF, et al.Brain MR imaging in neonatal hyperammonemic encephalopathy resulting from proximal urea cycle disorders. AJNR Am J Neuroradiol. 2003;24(6):11847.Google ScholarPubMed