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Monotone Semiflows Generated by Neutral Functional Differential Equations With Application to Compartmental Systems

Published online by Cambridge University Press:  20 November 2018

Jianhong Wu
Affiliation:
Department of Mathematics, York University, North York, Ontario M3J 1P3
H. I. Freedman
Affiliation:
Applied Mathematics Institute, Department of Mathematics, University of Alberta, Edmonton, Alberta T6G 2G1
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Abstract

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This paper is devoted to the machinery necessary to apply the general theory of monotone dynamical systems to neutral functional differential equations. We introduce an ordering structure for the phase space, investigate its compatibility with the usual uniform convergence topology, and develop several sufficient conditions of strong monotonicity of the solution semiflows to neutral equations. By applying some general results due to Hirsch and Matano for monotone dynamical systems to neutral equations, we establish several (generic) convergence results and an equivalence theorem of the order stability and convergence of precompact orbits. These results are applied to show that each orbit of a closed biological compartmental system is convergent to a single equilibrium.

Type
Research Article
Copyright
Copyright © Canadian Mathematical Society 1991

References

1. Alikakos, N.D. and Bates, P.W., Stabilization of solutions for a class of degenerate equations in divergence form in one space dimension, J. Differential Equations 73 (1988), 363393.Google Scholar
2. Alikakos, N.D. and Hess, P.H., On the stabilization of discrete monotone dynamical systems, Israel J. Math. 59 (1987), 185194.Google Scholar
3. Alikakos, N.D., Hess, P.H. and Matano, H., Discrete ordering-preserving semigroups and stability for periodic parabolic differential equations, J. Differential Eqns. 82 (1989), 322341.Google Scholar
4. Amann, H., Fixed point equations and nonlinear eigenvalue problems in ordered Banach spaces, SIAM Rev. 18 (1976), 620709.Google Scholar
5. Anderson, D.H., Compartmental modeling and tracer kinetics. Lecture Notes in Biomathematics, 56, Springer-Verlag, Heidelberg, 1983.Google Scholar
6. Araki, M. and Mori, T., On stability criteria for the composite systems including time delays, Trans. SICE 15:2 (1979), 267268.Google Scholar
7. Arino, O. and Hasurgui, E., On the asymptotic behavior of solutions of some delay differential systems which has a first integral, J. Math. Anal. Appl. 122 (1987), 3646.Google Scholar
8. Arino, O. and Seguier, P., About the behavior at infinity ofsolutions of x(t) = f(t — 1,x(t— 1)j —f(t,x(t)), J. Math. Anal. Appl. 96 (1983), 420436.Google Scholar
9. Bellman, R., Topics in pharmacokinetics-I: Concentration-dependent rates, Math. Biosci. 6 (1970), 1317.Google Scholar
10. Bellman, R., Topics in pharmacokinetics-H: Identification of time-lag processes, Math. Biosci. 11 (1971), 337- 342.Google Scholar
11. Bernier, C. and Manitius, A., On semigroups in Rn x LP corresponding to differential equations with delay, Can. J. Math. 30 (1978), 897914.Google Scholar
12. Burns, J.A., Herdman, T.L. and Stech, H.W., The Cauchy problem for linear functional differential equations. Proc. Conf. Integral and Functional Differential Equations, (Herdman, T.L., Stech, H.W. and Rankin, S.M. eds.), Marcel Deker, New York, 1981, 1981–139.Google Scholar
13. Burns, J.A., Linear functional differential equations as semigroups in product spaces, SIAM J. Math. Anal. 14 (1983), 98116.Google Scholar
14. Cooke, K.L. and Kaplan, J.L., A periodicity threshold theorem for epidemics and population growth, Math. Biosci. 31 (1976), 87107.Google Scholar
15. Cooke, K.L. and Yorke, J., Some equations modelling growth process and gonorrhea epidemics, Math. Biosci 16 (1973), 75101.Google Scholar
16. Cruz, M.A. and Hale, J.K., Stability of functional differential equations of neutral type, J. Differential Equations7 (1970), 334355.Google Scholar
17. Tongyen, Ding, Asymptotic behavior of solutions of some retarded differential equations, Scientia Sinica (A) 25: 4 (1982), 363370.Google Scholar
18. Eisenfeld, J., On approach to equilibrium in nonlinear compartmental systems. Differential Equations and Applications in Ecology, Epidemics and Population Problems , (S.N. Busenberg and K.L. Cooke, eds), Academic Press, New York, 1981, 119246.Google Scholar
19. Györi, I., Connections between compartmental systems with pipes and integrodifferential equations, Mathematical Modelling 7 (1987), 12151238.Google Scholar
20. Györi, I. and Eller, J., Compartmental systems with pipes, Math. Biosci. 53(1981 ), 223247.Google Scholar
21. Györi, I. and Jianhong Wu, A neutral equation arising from compartmental systems with pipes, J. Dynamics and Differential Eqns. (to appear).Google Scholar
22. Haddock, J.R., Krisztin, T. and Jianhong Wu, Asymptotic equivalence of neutral equations and infinite delay equations, Nonlin. Anal. TMA 14 (1990), 369377.Google Scholar
23. Haddock, J.R. and Terjeki, J., Liapunov-Razumikhin functions and invariance principle for Junctional differential equations, J. Differential Equations 48 (1983), 95122.Google Scholar
24. Hale, J.K. Theory of Functional Differential Equations. Springer-Verlag, New York, 1977.Google Scholar
25. Hale, J.K. and Massatt, P., Asymptotic behavior of gradient-like systems. Dynamical Systems II, (A.R. Bednark and L. Cesari, eds.), 85102.Google Scholar
26. Hess, P., On stabilization of discrete strongly order-preserving semigroups and dynamical processes. Proceedings of Trends in Semigroup Theory and Applications, Trieste, September 18-October 2, 1987.Google Scholar
27. Hirsch, M., The dynamical systems approach to differential equations, Bull. Amer. Math. Sci. 11 (1984), 164.Google Scholar
28. Hirsch, M., Stability and convergence in strongly monotone dynamical systems, J. Reine Angew. Math. 383(1988), 153.Google Scholar
29. Jacquez, J.A., Compartmental Analysis. Biology and Medicine, Elsevier, Amsterdam, 1972.Google Scholar
30. Kaplan, J.K., Sorg, M. and York, J., Solutions of x(t) = f(x(t),x(t — L)) have limits whenf is an order relation, Nonlin. Anal., TMA 3:1 (1979), 5358.Google Scholar
31. Kunish, K. and Schappacher, W., Order preserving evolution operators of functional differential equations, Bull Un. Mat. Ital. B(6)2(1979), 480500.Google Scholar
32. Ladde, G.S., Cellular systems H-Stability of compartmental systems, Math. Biosci. 30 (1976), 121.Google Scholar
33. Lakshmikantham, V. and Leela, S., Differential and Integral Inequalities (II). Academic Press, New York, 1969.Google Scholar
34. Lewis, R.M. and Anderson, B., Insensitivity of a class of nonlinear compartmental systems to the introduction of arbitrary time delays, IEEE Trans. Circ. Syst. CAS-27(7)(1980), 604611.Google Scholar
35. Lopes, O., Forced oscillations in nonlinear neutral differential equations, SIAM J. Appl. Math. 29 (1975), 195207.Google Scholar
36. Matano, H., Convergence of solutions of one-dimensional semilinear parabolic equations, J. Math. Kyoto U. 18 (1978), 221227.Google Scholar
37. Matano, H., Asymptotic behavior and stability of solutions of semilinear diffusion equations, Publ. Res. Inst. Math. Sci., Koyoto 5 (1979), 410454.Google Scholar
38. Matano, H., Existence ofnontrivial unstable sets for equilibriums of strongly order preserving systems, J. Fac. Sci., U. Kyoto, (1983), 645673.Google Scholar
39. Maeda, H. and Kodama, S., Qualitative analysis of a class of nonlinear compartmental systems: nonoscillation and asymptotic stability, Math. Biosci. 38 (1978), 3544.Google Scholar
40. Martin, R.H., Asymptotic behavior of solutions to a class of quasi-monotone functional differential equations. Abstract Cauchy Problems and Functional Differential Equations, (Kappel, F. and Schappacher, W., eds.) Pitman, New York, 1981.Google Scholar
41. Martin, R.H. and Smith, H.L., Reaction-diffusion systems with time delays: monotonicity, invariance, comparison and convergence, preprint.Google Scholar
42. Martin, R.H., Abstract functional differential equations and reaction-diffusion systems, Trans. Amer. Math. Soc. 321 (1990), 144.Google Scholar
43. Mazanov, A., Stability of multi-pool models with lags, J. Theoret. Biol. 59 (1976), 429442.Google Scholar
44. Melvin, W.R., A class of neutral functional differential equations,!. Differential Equations 12 (1972), 524- 534.Google Scholar
45. Ohta, Y., Qualitative analysis of nonlinear quasi-monotone dynamical systems described by functional differential equations, IEEE Trans. Circ. Syst. CAS-28(2)(1981), 138144.Google Scholar
46. Salamon, D., Control and Observation of Neutral Systems. Pitman, Boston, 1984.Google Scholar
47. Seifert, J.G. , Positively invariant closed sets for systems of delay differential equations, J. Differential Equations 22 (1976), 292304.Google Scholar
48. Smith, H., Systems of ordinary differential equations which generate an order preserving flow, a survey of results, SIAM Review 30 (1988), 87113.Google Scholar
49. Smith, H., Monotone semiflows generated by functional differential equations, J. Differential Equations 66 (1987), 420442.Google Scholar
50. Staffans, O.J., A neutral FDE with stable D-operator is retarded, J. Differential Equations 49(1983), 208217.Google Scholar
51. Takač, P., Convergence to equilibrium on invariant d-hypersurface for strongly increasing discrete-time semigroup, preprint.Google Scholar
52. Wu, J., On Haddock's conjecture, Applicable Analysis 33 (1989), 127137.Google Scholar
53. Wu, J. , Convergence of monotone dynamical systems with minimal equilibria, Proc. Amer. Math. Soc. (1989), 907911.Google Scholar