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SGEM Hot Off the Press: hypertonic saline in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

Published online by Cambridge University Press:  13 September 2016

Eve Purdy*
Affiliation:
Department of Emergency Medicine, Queen’s University, Kingston, ON
Brent Thoma
Affiliation:
Department of Emergency Medicine, University of Saskatchewan, Saskatoon, SK
Ken Milne
Affiliation:
Division of Emergency Medicine, Western University, London, ON
Chris Bond
Affiliation:
Department of Emergency Medicine, University of Calgary, Calgary, AB.
*
Correspondence to: Eve Purdy, Department of Emergency Medicine, Kingston General Hospital, c/o 76 Stuart Street, Kingston, ON K7L 2V7; Email: [email protected]

Abstract

As part of the Canadian Journal of Emergency Medicine’s (CJEM) developing social media strategy,1 we are collaborating with the Skeptics’ Guide to Emergency Medicine (SGEM) to summarize and critically appraise the current emergency medicine (EM) literature using evidence-based medicine principles. In the “Hot Off the Press” series, we select original research manuscripts published in CJEM to be featured on the SGEM website/podcast and discussed by the study authors and the online EM community. A similar collaboration is under way between the SGEM and Academic Emergency Medicine. What follows is a summary of the selected article, the immediate post-publication synthesis from the SGEM podcast, commentary by the first author, and the subsequent discussion from the SGEM blog and other social media. Through this series, we hope to enhance the value, accessibility, and application of important, clinically relevant EM research. In this, the second SGEM HOP hosted collaboratively with CJEM, we discuss a systematic review evaluating the use of hypertonic saline in the treatment of severe traumatic brain injury.2

Type
Original Research
Copyright
Copyright © Canadian Association of Emergency Physicians 2016 

Introduction

Severe traumatic brain injuries (TBIs) are common in Canadian emergency departments.Reference Zygun, Laupland and Hader 2 These injuries are associated with high morbidity and mortality.Reference Turgeon, Lauzier and Simard 3 In addition to the damage from primary trauma, secondary cerebral injuries can occur as a result of increased intracranial pressure (ICP). Because raising ICP is a mechanism for mortality and poor neurologic outcomes, a number of interventions target this disease mechanism.Reference Park, Bell and Baker 4 Treatment approaches include, but are not limited to, cerebrospinal fluid drainage, decompressive craniectomy, and barbiturate coma.Reference Bullock, Chestnut and Ghajar 5 However, the first-line treatment most often consists of intravenous infusion of a hyperosmolar solution. 6

Mannitol is the hyperosmolar solution recommended by multiple clinical practice guidelines and is considered to be the gold standard for hyperosmolar therapy. 6 However, a well-known adverse effect of this treatment is diuresis, which can lead to hypotension, a state that is associated with higher mortality in TBI patients.Reference Wakai, Roberts and Schierhout 7 - Reference McGraw and Howard 9 Hypertonic saline solutions have been proposed as an alternative to mannitol because they have both volume repletion properties and provide the desired osmotic effect. Six previous systematic reviews have compared mannitol to hypertonic saline, but their validity has been questioned because they used low-sensitivity search strategies, did not include the most recent evidence, included non-randomized controlled trials (non-RCTs), and included patients with nontraumatic causes of elevated ICP.Reference Barbic, Barbic and Lang 10 - Reference Wade, Grady and Kramer 15

Summary

Berger-Pelletier et al. conducted a literature search to identify RCTs comparing hypertonic saline to hyperosmolar solutions (mannitol or sodium bicarbonate), iso-osmolar solutions (normal saline or ringer’s lactate), or hypo-osmolar solutions. They searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Scopus, Web of Science, BIOSIS databases, grey literature, and the reference sections of selected articles in a search that was not limited by language.

They found 21 relevant studies, each of which was reviewed by two authors who independently extracted data. Eleven of these articles were included in the qualitative analysis, and nine were included in the quantitative analysis. The 11 studies that met the inclusion criteria on full-text review included 1820 patients (the vast majority of which were >18 years old) with TBIs. The risk of bias was performed using a standardized tool.

Quality Assessment

We used the Best Evidence in Emergency Medicine (BEEM) tool as a reference in our critical appraisal of this systematic review.Reference Guyatt, Rennie and Meade 16 , Reference Worster 17

This study addressed a clinically relevant, patient-oriented outcome (mortality) as the primary outcome and a disease-oriented outcome (measured ICP) as a secondary outcome. The authors’ search strategy was detailed and exhaustive. In particular, their exploration of the grey literature and inclusion of studies in all languages was particularly impressive. Two independent authors screened the titles and abstracts for a full-text review.

Unfortunately, most of the available RCTs were small in size. Of the 11 included studies, only 3 registered more than 100 patients, and 1 large study comprising 1282 patients made up 70% of the patient population. Only two of the studies included were at low risk of bias with the rest suffering from methodological flaws related to blinding and a lack of outcome data.

The authors planned a priori to evaluate secondary outcomes, including neurologic outcomes at the intensive care unit or hospital discharge and hospital length of stay. Unfortunately, a quantitative evaluation of these outcomes was not possible due to under-reporting.

Results

The evidence for hypertonic saline for ICP in TBI, as reviewed by Berger-Pelletier et al., comes from a group of studies, most of which are quite small and at risk of bias. The authors conclude that hypertonic saline cannot be recommended as a first-line agent for managing patients with TBI.

Methodology

The social media discussion started with the launch of the blog post and podcastReference Milne 18 on March 27, 2016, and continued for 1 week through April 3, 2016. An invitation to comment on the article was included in the audio of the podcast, the text of the blog post, and on social media communications (Twitter and Facebook). Throughout the week, multiple reposts of the article were made on Twitter. Social media responses written in the SGEM blog’s comment section, the SGEM Facebook page, and on Twitter (directed at @thesgem, @socmobem, @ElysePelletier and/or, using the #SGEMHOP hashtag) were reviewed by the authorship team.

Multiple metrics of dissemination were tracked by the SGEM HOP team:

  • Blog post page views were monitored using the Jetpack plugin by Wordpress.com. 19

  • Facebook “reach” analytics were provided by Facebook and correlate to the number of users who saw the original SGEM Facebook page on their own newsfeed. Facebook likes were also tracked. 20

  • Twitter impressions (the number of users whose newsfeeds contained a tweet featuring the #SGEMHOP hashtag) were tracked using Symplur, a software program that tracks health care related Twitter conversations. 21 Tweets not containing the hashtag were not tracked by Symplur. The number of impressions is calculated by taking the number of tweets per Twitter user using the #SGEMHOP hashtag and multiplying it by the number of followers that participant has.

  • The altmetric score is a relatively new way to track the disseminative impact of research articles online by tracking mentions on social media (e.g., Facebook, Twitter) and mentions on blogs, podcasts, and news outlets. 22 Limitations of the altmetric score include the inability to distinguish quality from popularity, “gaming” of dissemination through automated downloads and social media bots, and they do not capture those reading articles through traditional print media.Reference Trueger, Thoma and Hsu 23 The altmetric score of Berger-Pelletier’s article was compared to articles from the same issue of CJEM, all other articles published in CJEM, research articles from all other outlets, and the article covered in the first CJEM-SGEM HOP.Reference Luckett-Gatopoulos, Thoma and Milne 24 , Reference Milne 25

A thematic analysis, performed through an inductive approach, of blog comments and Twitter comments was carried out by E.P. Tweets and posts simply promoting the #SGEMHOP article were not included in the thematic analysis. E.P. identified themes that captured key discussion points across platforms. Then all authors, through a consensus-based content analysis, decided on quotes from the blog posts that were representative of the discussion. Of note, all original tweets, comments, and content are available online for independent review.

Results of The Social Media Response

Table 1 presents the social media uptake of the second SGEM HOP. During the 1-week period, #SGEMHOP was used in 103 tweets by 37 separate users. Thirty-three of these tweets were from this study’s authors or the CJEM account prompting Twitter users to engage in conversation, linking to the original CJEM article and the #SGEMHOP blog post. There was a bimodal distribution in the peak timing of Twitter activity correlating to the day of release and 3 days after release. Conversation using the hashtag effectively ended within 4 days. Although outside of the scope of our a priori 2-week analysis window, it should be noted that the online discussion was re-invigorated more than a month after the initial posting, resulting in six additional comments on the blog. The altmetric score for the article reached 46. While lower than the last article featured for SGEMHOP (76), this is the fifth highest score for articles published in CJEM article and within the top 5th percentile of altmetric scores for all published research (Figure 1). The mean altmetric score for other original research articles in this CJEM issue was 7 (1–46).

Figure 1 Screen capture of the altmetrics data. Available at: https://cambridgejournals.altmetric.com/details/6255240#score (accessed 16 April 2016).

Table 1 Aggregate analytic data on the SGEM discussion on various social media platforms for the 7 days following postingReference Chan, Rosenberg and Lin 27

Online Discussion Summary

There were many insightful comments on social media networks, with the best appearing directly on the SGEM blog. One Twitter user, @KirstyChallen, even made an infographic on the topic. Discussions across platforms had similar tones and content. Of particular note, study author Elyse Pelletier was engaged in all of the discussions on the blog, offering clarification regarding her study and clinical expertise regarding the use of hypertonic fluid therapy in TBI.

Overall, it was felt that the level of evidence supporting the use of hypertonic fluids in TBIs is inadequate. Justin Morgenstern highlighted the fact that, although this systematic review tempers some of the recent excitement around hypertonic saline, we should keep in mind that mannitol became the gold standard through a much less rigorous process of evidence acceptance. Brent Thoma questioned whether we have enough evidence to recommend mannitol as first-line therapy, linking to a Cochrane review showing a non-significant relative risk of 0.83 (95% CI 0.47 to 1.46) for mortality.Reference Wakai, Roberts and Schierhout 7 Nadim Lalani offered a sobering reminder that the rate of mortality in this population is very high and suggested that future studies should include outcomes related to neurologic outcome in patients who do survive. These respondents agreed that the outcomes of future trials treatment should have patient-oriented (not disease-oriented) outcomes and also include a more in-depth evaluation of adverse events, because these would likely be the impetus for a change in practice.

Questions were also raised surrounding the practicalities and costs associated with delivering these treatments. For example, Ryan Deedo, a flight physician, provided a practical perspective, noting that hypertonic saline is easier to store than mannitol, potentially making it a better choice in prehospital environments. This served as a reminder that evidence has to be interpreted within the context of which we work.

Interestingly, the Twitter poll, Figure 2, with 53 participants found that many physicians use hypertonic saline, a practice that differs from the authors’ conclusion that hypertonic saline should not be recommended as first-line therapy. Because the Twitter poll sampled a small number of unique emergency physicians, it may not be representative of the broader EM community; however, it suggests that at least some emergency physicians disagree with the authors’ conclusions and support the further study of this question.

Figure 2 Tweet from Ken Milne (@theSGEM) containing a poll on what hypertonic solution respondents use for traumatic brain injury.

There are several limitations to this study. First, we recognize that there is sampling bias of physicians engaging in social media discussions. We appreciate that those online likely represent a unique subset of emergency physicians who cannot be extrapolated to be representative of the entire profession. Furthermore, there were 37 unique contributions to the online Twitter discussion, which represents less than 5% of emergency physicians with a Twitter account.Reference Lulic and Kovic 26 Second, Twitter engagement captured only those discussions that include the #SGEMHOP hashtag, and it is possible that we missed other important discussions on the topic online. There were a relatively small number of comments on the blog given the large number of times it was viewed. In order to increase engagement, we could consider posing questions to readers with a time-delayed release of the #SGEMHOP expert commentary. Alternatively, we could re-evaluate the release date/time to maximize the likelihood that individuals will respond. The Jetpack software used to collect website analytics did not allow for the collection of some useful metrics that could better help characterize engagement (e.g., time spent on page and the geographic location of participants). It would also be useful to track the number of article downloads from the CJEM website. In future study of online journal club models, we would suggest using analytical software that is capable of capturing these metrics.

Conclusion

The second collaborative knowledge translation effort between CJEM and the SGEM was successful on a number of fronts. First, the featured article had higher altmetric scores than other original research articles in the same CJEM issue, lending support to the hypothesis that a targeted social media strategy promotes dissemination. Second, direct access to the author of this study through the comments section on the SGEM allowed readers the unique opportunity to seek clarification on the paper and the overall topic, even months after the initial discussion was posted. Third, the Twitter poll highlighted possible discordance between the authors’ conclusions that hypertonic saline cannot be recommended as first-line therapy and some physicians’ clinical utilization. Finally, the discussion on the blog led to the suggestion of several future directions of research on this topic.

Competing interests: None declared.

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Figure 0

Figure 1 Screen capture of the altmetrics data. Available at: https://cambridgejournals.altmetric.com/details/6255240#score (accessed 16 April 2016).

Figure 1

Table 1 Aggregate analytic data on the SGEM discussion on various social media platforms for the 7 days following posting27

Figure 2

Figure 2 Tweet from Ken Milne (@theSGEM) containing a poll on what hypertonic solution respondents use for traumatic brain injury.