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Improved neurologic outcomes after cardiac arrest with combined administration of vasopressin, steroids, and epinephrine compared to epinephrine alone

Published online by Cambridge University Press:  01 April 2015

Tudor Botnaru ,
Tawfeeq Altherwi  and
Jerrald Dankoff
Tudor Botnaru*
Affiliation:
Emergency Medicine Residency Program, McGill University Health Centre, Montreal, QC
Tawfeeq Altherwi
Affiliation:
Emergency Medicine Residency Program, McGill University Health Centre, Montreal, QC
Jerrald Dankoff
Affiliation:
Department of Emergency Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC
*
Correspondence to: Dr. Tudor Botnaru, Emergency Medicine Residency Program, McGill University Health Centre, 687 Pine Avenue West, Room A4.62, Montreal, QC H3A 1A1; [email protected]

Abstract

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Clinical question

Is a vasopressin, steroid, and epinephrine (VSE) protocol for in-hospital cardiac arrest resuscitation associated with better survival to hospital discharge with favourable neurologic outcome compared to epinephrine alone?

Article chosen

Mentzelopoulos S, Malachias S, Konstantopoulos D, et al. Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial. JAMA 2013;310:270-9.

Objective

To determine if a VSE protocol during cardiopulmonary resuscitation with hydrocortisone administration in patients with postresuscitative shock at 4 hours after return of spontaneous circulation would improve survival to hospital discharge with favourable neurologic outcome.

Type
Knowledge to Practice: Journal Club
Information
Canadian Journal of Emergency Medicine , Volume 17 , Issue 2 , March 2015 , pp. 202 - 205
Copyright
Copyright © Canadian Association of Emergency Physicians 2015 

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