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Herpes Zoster Overlying Recently Placed Central Venous Access Site: A Case Report

Published online by Cambridge University Press:  27 July 2016

Rebecca A. Hess ,
Kyle Gunnerson  and
John Kahler
Rebecca A. Hess*
Affiliation:
University of Michigan Department of Emergency Medicine, Ann Arbor, MI.
Kyle Gunnerson
Affiliation:
University of Michigan Department of Emergency Medicine, Ann Arbor, MI.
John Kahler
Affiliation:
University of Michigan Department of Emergency Medicine, Ann Arbor, MI.
*
Correspondence to: Rebecca A. Hess, Department of Emergency Medicine, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109; Email: [email protected]

Abstract

Herpes zoster, commonly called shingles, is a disease that results from the reactivation of varicella zoster virus. Local trauma has been reported as a precipitant for reactivation, but this condition is rarely seen localized to a fresh surgical incision. We present the case of a patient who developed shingles overlying the incision site of a recently buried central venous access port, illustrating the need to consider this diagnosis as a unique imposter of localized infection or reaction at sites of recent procedural trauma.

Résumé

L’herpès zoster, communément appelé zona, est une maladie qui résulte de la réactivation du virus varicelle-zona. La documentation fait déjà mention de traumas locaux comme facteur précipitant de réactivation, mais le phénomène s’observe rarement au siège d’une incision chirurgicale récente. Sera décrit ici un cas de zona au point d’entrée d’un cathéter veineux central installé depuis peu, ce qui montre la nécessité d’envisager le diagnostic comme seul déclencheur d’infection localisée ou de réaction à des sièges d’intervention récente.

Keywords

ShinglesHerpes zosterBard PowerPortwound healing
Type
Case Reports
Information
Canadian Journal of Emergency Medicine , Volume 19 , Issue 1 , January 2017 , pp. 75 - 78
Copyright
Copyright © Canadian Association of Emergency Physicians 2016 

INTRODUCTION

Herpes zoster, commonly known as shingles, is a disease that results from reactivation of varicella zoster virus (VZV). It frequently manifests as a painful rash that starts as erythema and matures from maculopapular to vesicular, and pain may precede onset of the rash by days to weeks. The rash is usually unilateral and dermatomal, commonly in cranial or thoracic distributions.Reference Weiss 1 , Reference James, Berger and Elston 2 It erupts over three to five days, then crusts and gradually improves within two weeks.Reference Weiss 1

Shingles only occurs in patients who have had a previous primary infection with VZV, or chickenpox. Following resolution of the primary infection, it is believed that the virus lies dormant in the sensory dorsal root ganglia, and remains there for the duration of the patient’s life.Reference Weiss 1 , Reference Levy and Smyth 3 - Reference Jain, Manjunath and Jagadish 5

Outbreaks have been temporally related to preceding local trauma, surgeries, and other procedures.Reference Weiss 1 , Reference Mazur and Dolin 6 - Reference Choi, Kim and Lee 12 This case describes a patient who developed shingles within the incision site of a recent PowerPort® placement, a buried central venous access port. The case illustrates the need to consider this diagnosis as a unique imposter of localized infection or reaction at sites of recent surgical trauma.

CASE REPORT

A 44-year-old woman with a recent diagnosis of metastatic breast cancer presented to the emergency department (ED) for evaluation of a rash around her newly placed central venous access port site.

She had a Bard PowerPort® placed three weeks prior to presentation, and had already undergone one chemotherapy treatment a week prior, with doxorubicin and cyclophosphamide.

The rash appeared two days prior to patient presentation. She reported mild redness around the incision site, superior to the port. She then developed two raised red streaks, extending parallel from the port site along the course of the catheter. The day prior to presentation, she noticed several clear, fluid-filled vesicles over these streaks. The vesicles ruptured and the streaks coalesced into one large erythematous area.

The affected area was intensely pruritic, but not painful. Hydrocortisone cream provided no improvement.

Examination revealed a hemodynamically stable middle-aged woman with no notable findings other than the rash. Her port was palpable in the right anterior chest wall, with no tenderness to palpation. The skin immediately overlying the port was not erythematous. Superior to the port, there were two raised erythematous linear lesions with overlying vesicles, mostly ruptured, as demonstrated in Figure 1.

Figure 1 Rash over site of port placement.

Laboratory work-up revealed a normal CBC and basic metabolic panel. Blood cultures were sent due to the possibility of underlying infection.

The rash was initially thought to be consistent with an allergic reaction to the port, leakage of chemotherapy, or a port-site infection. This was suggested by the localized area and intense pruritis without reports of pain. Dermatology and Allergy/Immunology were consulted in the ED, and the patient was given the diagnosis of contact dermatitis of unknown source. Possible sources considered included the plastic tubing of the port, the metal within the port apparatus, or an unknown agent placed around the port site during chemotherapy infusion. She was given a prescription for desoximetasone, a synthetic steroid cream, and discharged home.

The patient returned to the ED 12 days later with an unrelated complaint. On examination, she was still noted to have an erythematous rash with vesicles overlying her port site. Dermatology was again consulted and performed a biopsy, which confirmed herpes zoster. The patient was prescribed a 14-day course of valacyclovir (1 gram TID), and her rash was improved on follow-up.

DISCUSSION

Shingles is typically a clinical diagnosis. However, the diagnosis can be confirmed by vesicle scrapings which reveal multinucleated giant cells, or with viral cultures of the vesicular fluid.Reference Levy and Smyth 3 Histology reveals inflammation and neuronal loss within the ganglia corresponding to the affected dermatome.Reference Gilden, Kleinschmidt-DeMasters and LaGuardia 13

Epidemiologic studies have demonstrated an increasing incidence of shingles in recent years.Reference Yawn and Gilden 14 It has been estimated that between 10% and 20% of the general population will develop shingles within their lifetime. Annually, somewhere between 300,000 and 600,000 cases are reported in the United States, with the majority occurring in patients over 50 years of age.Reference Schmader, George and Burchett 15 , Reference Straus, Ostrove and Inchauspé 16

Risk factors that increase the likelihood of developing shingles include immunosuppression, advanced age, certain neoplasms, and systemic illnesses.Reference Weiss 1 , Reference Mazur and Dolin 6 , Reference Gilden, Kleinschmidt-DeMasters and LaGuardia 13 , Reference Choo, Galil and Donahue 17 , Reference Arvin 18 - Reference Watson 20 The causes behind the reactivation of VZV are unclear.

Shingles can be precipitated by local trauma or procedures.Reference Weiss 1 , Reference Mazur and Dolin 6 - Reference Choi, Kim and Lee 12 In most of these reported cases, the rash developed within the same dermatome as the preceding trauma. However, there are a few cases reported where the rash was located within the actual incision site. This case illustrates how shingles, developing around an incision site, can mimic other causes of rash.

There have been very few reports of patients developing shingles within their surgical incisions. Godfrey et al. (2006) reported a patient who developed shingles with the surgical incision site of a thoracic surgery for scoliosisReference Godfrey, Brown and Stambough 10 , and Choi et al. (2012) published a case report of a patient who developed herpes zoster within the scar of a recent facial operation.Reference Choi, Kim and Lee 12 Other procedures previously described to incite shingles include radiotherapy,Reference Dunst, Steil and Furch 21 liver biopsy,Reference Levy and Smyth 3 axillary nerve block,Reference Percival 22 botulinum toxin injections,Reference Graber, Dover and Arndt 23 intra-articular injections, cryosurgery,Reference Lee and Ryman 24 spinal surgery,Reference Weiss 1 intubation,Reference Wackym, Gray and Avant 25 shiatsu massage,Reference Mumm, Morens and Elm 26 liposuction,Reference Andrews, Perdikis and Shack 27 corticosteroid injections,Reference Fernandes, Malliah and Stitik 28 and skin grafting.Reference Lin and Cinat 29

The pathophysiology behind reactivation of the virus has been postulated to be related to hyperemia, ganglia irritation from direct pressure, or the release of inflammatory mediators.Reference Weiss 1 , Reference Kennedy and Cohrs 30 , Reference Juel-Jensen 31 Multiple pathways likely lead to viral reactivation via transcription of the latent virus,Reference Oakley, Epstein and Sherlock 32 and the process involves specific cytokines, notably IL-6 and tumor necrosis factor alpha, and expression of specific viral proteins such as VP16.Reference Shimeld, Easty and Hill 33 - Reference Thompson and Sawtell 37

The concept of local trauma inciting VZV reactivation has been explored.Reference Desborough 36 The mechanism in which shingles localizes to an actual incision site is even less clear, but perhaps relates to physiologic changes that occur locally at the site of the procedure, triggering hyperemia and loss of innate immunity.Reference Weiss 1 , Reference Juel-Jensen 31 , Reference Hill and Blyth 38

As outlined by Gadient et al. (2014), the time frame between the preceding procedure and the development of the rash is variable.Reference Gadient, Smith and Ryan 11 Thomas et al. (2004) published a case-control study showing elevated risks of shingles for a month following trauma;Reference Thomas, Wheeler and Hall 39 another study showed an elevated risk for two years following radiotherapy for breast cancer.Reference Dunst, Steil and Furch 21

The goals for treating shingles are to lessen the duration of the patient’s symptoms, to decrease the risk of transmission, and to prevent post-herpetic neuralgia. Post-herpetic neuralgia is a syndrome of cutaneous hypersensitivity and neuropathic pain that develops in roughly 10% to 15% of patients and is particularly difficult to treat.Reference Choo, Galil and Donahue 17 It is more commonly seen in older patients and in patients that present with a more extensive rash. The natural course of shingles is that it will spontaneously resolve without treatment; thus, the decision regarding whether to treat with antivirals is weighed based on the extent of the rash, the risk of developing complications, and the underlying health of the patient. Standard treatment regimens includes acyclovir (800 mg 5x/day) or valacyclovir (1,000 mg 3x/day), and should be started within 72 hours of onset of the rash. In immunocompetent patients, treatment should last five days; longer treatment, or IV antivirals, may be considered in immunocompromised patients. In patients that do not warrant antiviral therapy, treatment should focus on analgesia.

Returning to our case, a 44-year-old woman with metastatic breast cancer, immunosuppressed and on chemotherapy, presented with an erythematous and vesicular rash around her recently placed port site. Shingles should be considered in any vesicular rash, especially if the patient is immunosuppressed. Our patient was evaluated by Dermatology in the ED, which is not a common situation. It is more common that the diagnosis will need to be made clinically, without a punch biopsy, or patients may need to be presumptively treated until they can be evaluated in a clinic setting. Although our patient had delays in diagnosis and treatment until late in the course of her disease, she has had no signs of post-herpetic neuralgia documented on follow-up. It can be argued that the patient did not warrant antiviral therapy, as she presented late in the course of the disease and had a fairly limited distribution of rash. However, the decision was ultimately made to treat her because of the critical location of the rash over her port, which needed to be accessed frequently for chemotherapy. The duration of the patient’s treatment (14 days) is also longer than is typically recommended, and potentially put the patient at risk for more medication side effects than necessary.

CONCLUSION

Although the mechanism behind shingles remains unclear, this case illustrates the potential for local trauma, even if iatrogenic, to precipitate VZV reactivation. Rashes may appear atypical or follow odd distributions when related to procedures. Shingles is frequently misidentified as bacterial infections or local reactions causing pain or rash. Medical practitioners are reminded of this potential cause of shingles, as diagnostic testing or prompt recognition may improve outcome.

Competing Interests: None declared.

References

1. Weiss, R. Herpes zoster following spinal surgery. Clin Exp Dermatol 1989;14(1):56-57.Google Scholar
2. James, WD, Berger, TG, Elston, DM. Andrews’ Diseases of the Skin: Clinical Dermatology. 11th ed. London: Saunders Elsevier; 2011.Google Scholar
3. Levy, JM, Smyth, SH. Reactivation of herpes zoster after liver biopsy. J Vasc Interv Radiol 2002;13(2 Pt 1):209-210.Google Scholar
4. Hope-Simpson, RE. The Nature of Herpes Zoster: A Long-Term Study and a New Hypothesis. Proc R Soc Med 1965;58:9-20.Google Scholar
5. Jain, MK, Manjunath, KS, Jagadish, SN. Unusual oral complications of herpes zoster infection: report of a case and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110(5):e37-e41.Google Scholar
6. Mazur, MH, Dolin, R. Herpes zoster at the NIH: a 20 year experience. Am J Med 1978;65(5):738-744.CrossRefGoogle Scholar
7. Massad, MG, Navarro, RA, Rubeiz, H, et al. Acute postoperative shingles after thoracic sympathectomy for hyperhidrosis. Ann Thorac Surg 2004;78(6):2159-2161.CrossRefGoogle ScholarPubMed
8. Nikkels, AF, Piérard, GE. Shingles developing within recent surgical scars. J Am Acad Dermatol 1999;41(2 Pt 2):309-311.Google Scholar
9. Foye, PM, Stitik, TP, Nadler, SF, et al. A study of post-traumatic shingles as a work related injury. Am J Ind Med 2000;38(1):108-111.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
10. Godfrey, EK, Brown, C, Stambough, JL. Herpes zoster--varicella complicating anterior thoracic surgery: 2 case reports. J Spinal Disord Tech 2006;19(4):299-301.Google Scholar
11. Gadient, PM, Smith, JH, Ryan, SJ. Herpes zoster ophthalmicus following onabotulinumtoxinA administration for chronic migraine: a case report and literature review. Cephalalgia 2015;35(5):443-448.Google Scholar
12. Choi, HJ, Kim, JH, Lee, YM. Herpes zoster developing within recent subciliary incision scar. J Craniofac Surg 2012;23(3):930-931.Google Scholar
13. Gilden, DH, Kleinschmidt-DeMasters, BK, LaGuardia, JJ, et al. Neurologic complications of the reactivation of varicella-zoster virus. N Engl J Med 2000;342(9):635-645.Google Scholar
14. Yawn, BP, Gilden, D. The global epidemiology of herpes zoster. Neurology 2013;81(10):928-930.Google Scholar
15. Schmader, K, George, LK, Burchett, BM, et al. Racial differences in the occurrence of herpes zoster. J Infect Dis 1995;171(3):701-704.CrossRefGoogle ScholarPubMed
16. Straus, SE, Ostrove, JM, Inchauspé, G, et al. NIH conference. Varicella-zoster virus infections. Biology, natural history, treatment, and prevention. Ann Intern Med 1988;108(2):221-237.Google Scholar
17. Choo, PW, Galil, K, Donahue, JG, et al. Risk factors for postherpetic neuralgia. Arch Intern Med 1997;157(11):1217-1224.CrossRefGoogle ScholarPubMed
18. Arvin, AM. Varicella-zoster virus. Clin Microbiol Rev 1996;9(3):361-381.Google Scholar
19. Dolin, R, Reichman, RC, Mazur, MH, et al. NIH conference. Herpes zoster-varicella infections in immunosuppressed patients. Ann Intern Med 1978;89(3):375-388.Google Scholar
20. Watson, CP. Postherpetic neuralgia: the importance of preventing this intractable end-stage disorder. J Infect Dis 1998;178(Suppl 1):S91-S94.Google Scholar
21. Dunst, J, Steil, B, Furch, S, et al. Herpes zoster in breast cancer patients after radiotherapy. Strahlenther Onkol 2000;176(11):513-516.Google Scholar
22. Percival, NJ. Shingles following axillary nerve block. A case report. J Hand Surg Br 1986;11(1):115-116.Google Scholar
23. Graber, EM, Dover, JS, Arndt, KA. Two cases of herpes zoster appearing after botulinum toxin type a injections. J Clin Aesthet Dermatol 2011;4(10):49-51.Google Scholar
24. Lee, MR, Ryman, W. Herpes zoster following cryosurgery. Australas J Dermatol 2005;46(1):42-43.Google Scholar
25. Wackym, PA, Gray, GF Jr, Avant, GR. Herpes zoster of the larynx after intubational trauma. J Laryngol Otol 1986;100(7):839-841.Google Scholar
26. Mumm, AH, Morens, DM, Elm, JL, et al. Zoster after shiatsu massage. Lancet 1993;341(8842):447.Google Scholar
27. Andrews, TR, Perdikis, G, Shack, RB. Herpes zoster as a rare complication of liposuction. Plast Reconstr Surg 2004;113(6):1838-1840.Google Scholar
28. Fernandes, NF, Malliah, R, Stitik, TP, et al. Herpes zoster following intra-articular corticosteroid injection. Acta Dermatovenerol Alp Pannonica Adriat 2009;18(1):28-30.Google ScholarPubMed
29. Lin, P, Cinat, M. Herpes zoster involving a skin graft. J Burn Care Res 2010;31(5):813-815.Google Scholar
30. Kennedy, PG, Cohrs, RJ. Varicella-zoster virus human ganglionic latency: a current summary. J Neurovirol 2010;16(6):411-418.CrossRefGoogle ScholarPubMed
31. Juel-Jensen, BE. The natural history of shingles. Events associated with reactivation of varicella-zoster virus. J R Coll Gen Pract 1970;20(101):323-327.Google Scholar
32. Oakley, C, Epstein, JB, Sherlock, CH. Reactivation of oral herpes simplex virus: implications for clinical management of herpes simplex virus recurrence during radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84(3):272-278.Google Scholar
33. Shimeld, C, Easty, DL, Hill, TJ. Reactivation of herpes simplex virus type 1 in the mouse trigeminal ganglion: an in vivo study of virus antigen and cytokines. J Virol 1999;73(3):1767-1773.CrossRefGoogle Scholar
34. Sawtell, NM, Triezenberg, SJ, Thompson, RL. VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo. J Neurovirol 2011;17(6):546-551.Google Scholar
35. Thompson, RL, Sawtell, NM. The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections. J Neurovirol 2011;17(6):552-558.CrossRefGoogle ScholarPubMed
36. Desborough, JP. The stress response to trauma and surgery. Br J Anaesth 2000;85(1):109-117.CrossRefGoogle ScholarPubMed
37. Thompson, RL, Sawtell, NM. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J Virol 1997;71(7):5432-5440.Google Scholar
38. Hill, TJ, Blyth, WA. An alternative theory of herpes-simplex recurrence and a possible role for prostaglandins. Lancet 1976;1(7956):397-399.CrossRefGoogle Scholar
39. Thomas, SL, Wheeler, JG, Hall, AJ. Case-control study of the effect of mechanical trauma on the risk of herpes zoster. BMJ 2004;328(7437):439.Google Scholar
Figure 0

Figure 1 Rash over site of port placement.