Analysis of neurotransmitter levels in individual insect brains has been hampered by the unavailability of a suitable tissue homogenizer. Commercially-available homogenizers are expensive, often fragile, and generally ill-designed and cumbersome for handling microlitre volumes. This report describes the fabrication of an efficient, inexpensive microhomogenizer suitable for routine processing of small amounts of soft tissue using an idea suggested by Meek (1976).