Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-19T05:22:16.319Z Has data issue: false hasContentIssue false

Gene Doping—in Animals? Ethical Issues at the Intersection of Animal Use, Gene Editing, and Sports Ethics

Published online by Cambridge University Press:  20 December 2018

Abstract:

Gene editors such as CRISPR could be used to create stronger, faster, or more resilient nonhuman animals. This is of keen interest to people who breed, train, race, and profit off the millions of animals used in sport that contribute billions of dollars to legal and illegal economies across the globe. People have tried for millennia to perfect sport animals; CRISPR proposes to do in one generation what might have taken decades previously. Moreover, gene editing may facilitate enhancing animals’ capacities beyond their typical limits. This paper describes the state of animal use and engineering for sport, examines the moral status of animals, and analyzes current and future ethical issues at the intersection of animal use, gene editing, and sports. We argue that animal sport enthusiasts and animal welfarists alike should be concerned about the inevitable use of CRISPR in sport animals. Though in principle CRISPR could be used to improve sport animals’ well-being, we think it is unlikely in practice to do so.

Type
Special Section: Genome Editing: Biomedical and Ethical Perspectives
Copyright
Copyright © Cambridge University Press 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Notes

1. Ross D. Drugs in Sport. Lasix: the drug debate which is bleeding US horse racing dry. The Guardian; 2014 Aug 31; available at https://www.theguardian.com/sport/2014/aug/31/lasix-drug-debate-bleeding-horse-racing (last accessed 22 Mar 2018); Texts reveal extent of doping scandal in Aussie horse racing. USA Today; 2018 Feb 20; available at https://www.usatoday.com/story/sports/horseracing/2018/02/20/texts-reveal-extent-of-doping-scandal-in-aussie-horse-racing/110649694/ (last accessed 22 March 2018); Zarda B. The doping of the bulls. Popular Science; 2008 May 2; available at https://www.popsci.com/score/article/2008-05/doping-bulls (last accessed 22 Mar 2018); Steer disqualified for doping At Calgary stampede. The Huffington Post Alberta; 2013 Aug 13; available at http://www.huffingtonpost.ca/2013/08/13/steer-disqualified-for-doping-calgary-stampede_n_3750536.html (last accessed 22 Mar 2018). Iditarod sled dog race engulfed in dog-doping scandal. VOA News; 2017 Oct 24; available at https://www.voanews.com/a/iditarod-sled-dog-race-doping-scandal/4084473.html (last accessed 22 Mar 2018). Swenson K. Dog racing ‘has a drug problem’ as 12 Florida greyhounds test positive for cocaine. The Washington Post; 2017 July 6 (morning mix); available at https://www.washingtonpost.com/news/morning-mix/wp/2017/07/06/dog-racing-has-a-drug-problem-as-12-florida-greyhounds-test-positive-for-cocaine/?utm_term=.de6dca6628cf (last accessed 15 Mar 2018).

2. Derbyshire D. How genetics can create the next superstar racehorse. The Guardian; 2014 June 22 (genetics); available at https://www.theguardian.com/science/2014/jun/22/horse-breeding-genetics-thoroughbreds-racing-dna (last accessed 22 Mar 2018). Doucleff, M. Iditarod sled dog race. Cell. 2012 Mar 2; 148(5):839–41;Google Scholar Forto, R, Stein, A. Mushing Radio: Gene Doping in Sled Dog Sports [audio podcast]. Willow, AK: Dog Works Radio; 2017 [34 min].Google Scholar

3. DeGrazia, D. Moral status as a matter of degree? Southern Journal of Philosophy 2008;46(2):181–98;CrossRefGoogle Scholar DeGrazia, D, Sebo, J. Necessary conditions for morally responsible animal research. Cambridge Quarterly of Healthcare Ethics; 2015;24(4):420–30.CrossRefGoogle ScholarPubMed

4. Frey, RG. Utilitarianism and animals. In: Beauchamp, TL, Frey, RG, eds. The Oxford Handbook of Animal Ethics. New York: Oxford University Press; 2011:172–97, at 184.CrossRefGoogle Scholar

5. In setting up this discussion by showing differences in capacities between humans and other animals, we do not mean to imply that species membership is morally important. Rather, we aim to show that capacities, and the interests they generate, are relevant to determining what we owe to other creatures, regardless of species. As has been argued by Singer and others, species membership is less relevant to rights and moral worth than the demonstration of capacities and interests. See Singer P. Animal Liberation. New York: New York Review; 1975. See also DeGrazia D. Taking Animals Seriously: Mental Life and Moral Status. Cambridge: Cambridge University Press; 1996.

6. Beauchamp, TL. Rights theory and animal rights. In: Beauchamp, TL, Frey, RG, eds. The Oxford Handbook of Animal Ethics. New York: Oxford University Press; 2011:198227.CrossRefGoogle Scholar

7. Crowther, NB. Sport in Ancient Times. Norman: University of Oklahoma Press; 2010, at 17-18.Google Scholar

8. Orlans, BF, Beauchamp, TL, Dresser, R, Morton, DB, Gluck, JP. The Human Use of Animals: Case Studies in Ethical Choice. New York: Oxford University Press; 1998, at 92.Google Scholar

9. See Note 7, at 46.

10. Ibid., at 21.

11. The Jockey Club. Gross Purses 2018 [2 screens]; available at http://jockeyclub.com/default.asp?section=FB&area=7 (last accessed 22 Mar 2018).

12. Mitchell E. Kentucky stud fees: Cumulative list of announced Kentucky stud fees for 2017. Blood Horse; 2017 Nov 11; available at https://www.bloodhorse.com/horse-racing/articles/217639/2017-kentucky-stud-fees (last accessed 22 Mar 2018).

13. Derbyshire, D. How genetics can create the next superstar racehorse. The Guardian; 2014 June 22 (Genetics); available at https://www.theguardian.com/science/2014/jun/22/horse-breeding-genetics-thoroughbreds-racing-dna (last accessed 15 Mar 2018).Google Scholar

14. See Note 12.

15. See Note 13.

16. See Note 7, at 132–3.

17. Swenson, K. Dog racing ‘has a drug problem’ as 12 Florida greyhounds test positive for cocaine. The Washington Post; 2017 July 6 (Morning Mix); available at https://www.washingtonpost.com/news/morning-mix/wp/2017/07/06/dog-racing-has-a-drug-problem-as-12-florida-greyhounds-test-positive-for-cocaine/?utm_term=.de6dca6628cf (last accessed 15 Mar 2018).Google Scholar

18. Ibid.

19. Associated Press. Iditarod sled dog race engulfed in dog-doping scandal. VOA News; 2017 Oct 24 (Arts & Entertainment); available at https://www.voanews.com/a/iditarod-sled-dog-race-doping-scandal/4084473.html (last accessed 15 Mar 2018).

20. Forto, R, Stein, A. Mushing Radio: Gene Doping in Sled Dog Sports [audio podcast]. Willow, AK: Dog Works Radio; 2017 [34 min].Google Scholar

21. Begley S. Do CRISPR enthusiasts have their head in the sand about the safety of gene editing? State News; 2015 Jul 18 (In the Lab); available at https://www.statnews.com/2016/07/18/crispr-off-target-effects/ (last accessed 22 Mar 2018).

22. Gazda MA, Andrade P, Afonso S, Dilyte J, Archer JP, Lopes RJ, et al. Signatures of selection on standing genetic variation underlie athletic and navigational performance in racing pigeons. Molecular Biology and Evolution; 2018 Mar 13; available at https://academic.oup.com/mbe/article-abstract/35/5/1176/4911169?redirectedFrom=fulltext (last accessed 14 Sept 2018).

23. Doucleff, M. Iditarod sled dog race. Cell 2012 Mar 2;148(5):839–41.Google Scholar

24. Regalado, A. First gene-edited dogs reported in China. MIT Technology Review; 2015 Oct 19 (Rewriting Life); available at https://www.technologyreview.com/s/542616/first-gene-edited-dogs-reported-in-china/ (last accessed Mar 22, 2018).Google Scholar

25. Rosenblum, A. A biohacker’s plan to upgrade Dalmatians ends up in the doghouse. MIT Technology Review; 2017 Feb 1 (Rewriting Life); available at https://www.technologyreview.com/s/603530/a-biohackers-plan-to-upgrade-dalmatians-ends-up-in-the-doghouse (last accessed 22 Mar 2018).Google Scholar

26. See Note 20.

27. Zayner, Josiah, quoted in Jacobson, R. Hacking your genes has never been easier. Outside Online; 2017 Sept 6 (Features); available at https://www.outsideonline.com/2238276/ultimate-life-hack (last accessed 22 Mar 2018).Google Scholar

28. Dugatkin, LA, Rodrigues, S. Games animals play. Greater Good Magazine; 2008 Mar 1 (Articles & More) [cited 2018 Mar 15]; available at https://greatergood.berkeley.edu/article/item/games_animals_play (last accessed 22 Mar 2018).Google Scholar

29. Markwell, K, Firth, T, Hing, N. Blood on the race track: An analysis of ethical concerns regarding animal-based gambling. Annals of Leisure Research; 2017;20(5):594609.CrossRefGoogle Scholar

30. Walker, R. Human and animal subjects of research: The moral significance of respect versus welfare. Theoretical Medicine and Bioethics; 2006;27:305–31, at 319.CrossRefGoogle ScholarPubMed

31. Ibid.

32. Fenton A. Can a chimp say “No”? Cambridge Quarterly of Healthcare Ethics 2014;23:130–9, at 134.

33. Shriver, A. Knocking out pain in livestock: Can technology succeed where morality has stalled? Neuroethics 2009;2(3):115–24;CrossRefGoogle Scholar Shriver, A, McConnachie, E. Genetically modifying livestock for improved welfare: A path forward. Journal of Agricultural and Environmental Ethics ; 2018 Mar 3:120.Google Scholar