In his book, Illness and Culture in the Postmodern Age (University of California Press, 1998), David B. Morris offers a biocultural model in which illness, with its biological and cultural components, always stands at the crossroads of both biology and culture. Given Morris's point that illness is a biocultural construct, it follows that individual and institutional decisionmaking in healthcare also involve a biocultural construct that experience suggests is too often overlooked, to the detriment of all decisionmakers. In the following Special Section, “Culture, Health, and Bioethics,” the authors explore the importance of understanding the cultural processes and concomitant challenges that necessarily play a crucial role as patients, providers, and policymakers grapple with healthcare decisions.