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Four Paradigms of Clinical Research and Research Oversight

Published online by Cambridge University Press:  06 December 2006

EZEKIEL J. EMANUEL  and
CHRISTINE GRADY
EZEKIEL J. EMANUEL
Affiliation:
W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
CHRISTINE GRADY
Affiliation:
W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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Extract

The understanding of appropriate ethical protections for participants of biomedical research has not been static. It has evolved over time, with the evolution of biomedical research as well as social values. Since World War II, there have been four major paradigms of research and research oversight operative in the United States (Table 1). These paradigms incorporate different values and provide different approaches to research oversight and the protection of research participants.

Type
SPECIAL SECTION: OPEN FORUM
Information
Cambridge Quarterly of Healthcare Ethics , Volume 16 , Issue 1 , January 2007 , pp. 82 - 96
Copyright
© 2007 Cambridge University Press

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