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Why is an Egg Donor a Genetic Parent, but not a Mitochondrial Donor?

Published online by Cambridge University Press:  12 July 2019

Abstract:

As new ways of reproducing emerge, advancing technologies are forcing us to rethink our old ideas of what it means to be a genetic parent. Why should some processes qualify as “reproduction” and others should not? To illustrate the practical impact of providing a defensible account of reproduction, the author examines the case of mitochondrial donation (mtDNA) and calls for a philosophical argument to bring clarity to exactly what we mean by ‘reproduction.’

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Articles
Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

Acknowledgments: Special thanks to Sean Allen-Hermanson, Tim Lewens, Matt Mosdell, Robert Sparrow, Jim Tabery, and anonymous reviewers for their careful reading and constructive criticism.

References

Notes

1. Gallagher J. MPs say yes to three-person babies. BBC News 3 Feb 2015; available at: http://www.bbc.com/news/health-31069173 (last accessed 24 July 2015).

2. The Human Fertilisation and Embryology Authority. Mitochondrial donation: Clinic staff guide to consent. Version 1: 1–27 2015; available at: http://www.hfea.gov.uk/9939.html (last accessed 24 July 2015).

3. Nuffield Council on Bioethics. Novel Techniques for the Prevention of Mitochondrial Disorders: An Ethical Review. London: Nuffield Council on Bioethics; 2012: XVI.Google Scholar

4. More than a handful of bioethicists have acknowledged the difficulty of identifying the genetic parents of offspring created through new reproductive technologies (most recently Douglas, T. 2014. Stem cell-derived gametes, iterated in vitro reproduction, and genetic parenthood. Journal of Medical Ethics 40: 723–4;CrossRefGoogle ScholarPubMed Mertes, H. 2014. Gamete derivation from stem cells: Revisiting the concept of genetic parenthood. Journal of Medical Ethics 40: 744–7,CrossRefGoogle ScholarPubMed but see also Alpern, KD. 1992. Genetic puzzles and stork stories. In: Alpern, KD, ed. The Ethics of Reproductive Technology. Oxford: Oxford University Press; 147–69;Google Scholar Kolers, A, Bayne, T. 2001. Are you my mommy? On the genetic basis of parenthood. Journal of Applied Philosophy 18:273–85;CrossRefGoogle Scholar Kolers, A, Bayne, T. Toward a pluralistic account of parenthood. Bioethics 2003;17:221–42;Google Scholar Kolers, A. Cloning and genetic parenthood. Cambridge Quarterly of Healthcare Ethics 2003;12:401–10;CrossRefGoogle ScholarPubMed Mertes, H & Pennings, G. Embryonic stem cell-derived gametes and genetic parenthood: A problematic relationship. Cambridge Quarterly of Healthcare Ethics 2008;17:714;CrossRefGoogle ScholarPubMed Silver, LM & Silver, SR. Confused heritage and the absurdity of genetic ownership. Harvard Journal of Law & Technology 1998;11:593618;Google ScholarPubMed Sparrow, R. Cloning, Parenthood, and Genetic Relatedness. Bioethics 2006;20:308–18;CrossRefGoogle Scholar Sparrow, R. Orphaned at conception: The uncanny offspring of embryos. Bioethics 2012;26:173–81).CrossRefGoogle ScholarPubMed However, instead of seeing this as a reason to rethink our existing concept of reproduction, as I am proposing, the trend (with a few exceptions) has been to either abandon the genetic notion of parenthood all together, or to hold on to the traditional concept of sexual reproduction and use it to decide who is and is not a genetic parent.

5. Ad Hoc Committee of the Harvard Medical School. A definition of irreversible coma—Report of the ad hoc committee of the Harvard Medical School to examine the definition of brain death. JAMA 1968;205:337–40.CrossRefGoogle Scholar

6. President’s Commission. Defining death: Medical, legal and ethical issues in the determination of death. Report of the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research 1981:33.

7. President’s Commission, op. cit. note 5, p. 58.

8. McMahan, J. Killing embryos for stem cell research. Metaphilosophy 2007;38:170–89, at 181.CrossRefGoogle Scholar

9. Bernat, JL, Culver, CM & Gert, B. On the definition and criterion of death. Annals of Internal Medicine 1981;94:389–94,CrossRefGoogle ScholarPubMed op. cit. note 6, at 390.

10. President’s Commission. op. cit. note 5, at 55.

11. Consider, for example, the recent case of the Benioff Children’s Hospital and Jahi McMath. Going against the family’s wishes, the hospital refused to take care of Jahi once she was declared brain dead (S. Lupkin. 2015. Family California Teen Declared Brain Dead Sues Hospital for Malpractice. ABC News 3 March; available at http://abcnews.go.com/Health/family-california-teen-declared-brain-dead-sues-hospital/story?id=29363442 (last accessed 24 July 2015).

12. Only mothers pass down mitochondrial genes to their children.

13. See note 3, Nuffield Council on Bioethics 2012, at 53.

14. See note 3, Nuffield Council on Bioethics 2012, at 77.

15. For an argument as to why there are no “genes for” traits, see Lewens, T. Development aid: On ontogeny and ethics. Studies in History and Philosophy of Biological and Biomedical Sciences 2002;33:195217.CrossRefGoogle Scholar

16. Han, X, Chen, M, Wang, F, Windrem, M, Wang, S, Shanz, S, et al. Forebrain engraftment of human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 2013;12:342–53.CrossRefGoogle ScholarPubMed

17. See note 16, Han et al. 2016, at 349.

18. Windrem, MS, Schanz, SJ, Morrow, C, Munir, J, Chandler-Militello, D, Wang, S, Goldman, SA. A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia. The Journal of Neuroscience 2014;34:16153–61, at 16153.CrossRefGoogle ScholarPubMed

19. Macrae F. Miracle or meddling? ‘Chimeric’ monkeys made from cells of six different ‘parents’ spark protests. The Daily Mail 6 Jan 2012.; available at: http://www.dailymail.co.uk/sciencetech/article-2082891/Miracle-meddling-Chimeric-monkeys-cells-different-parents-spark-protests.html (last accessed 24 July 2015).

20. Johnston, J. Tied up in nots over genetic parentage. Hastings Center Report 2007;37:2831, at 28.CrossRefGoogle ScholarPubMed

21. Human Fertilisation and Embryology Authority. Code of practice: Consent to treatment, storage, donation, training and disclosure of information – interpretation of mandatory requirements: 5B 2009.; available at: http://www.hfea.gov.uk/336.html#otherLegislation (last accessed 24 July 2015).

22. The Human Fertilisation and Embryology Authority. Mitochondrial donation: Clinic staff guide to consent. Version 1: 14, 2015. Available at: http://www.hfea.gov.uk/9939.html (last accessed 24 July 2015).

23. The Human Fertilisation and Embryology Authority (Disclosure and Donor Information) Regulations 2004; available at: http://www.legislation.gov.uk/uksi/2004/1511/contents/made (last accessed 24 July 2015).

24. The Human Fertilisation and Embryology Authority. HFEA Policies on Donation 2014; available at: http://www.hfea.gov.uk/5554.html (last accessed 24 July 2015).

25. For a discussion on this topic see Muireann, Q. A right to reproduce? Bioethics 2010;24:403–11.Google Scholar

26. See, for example, Campo-Engelstein ( Campo-Engelstein, L. Gametes or organs? How should we legally classify ovaries used for transplantation in the USA? Journal of Medical Ethics 2011;37:166–70CrossRefGoogle ScholarPubMed) for a discussion on the right not to reproduce in the context of ovarian tissue transplants that can lead to pregnancy.

27. Berkowitz ( Berkowitz, JM. Mummy was a fetus: Motherhood and fetal ovarian transplantation. Journal of Medical Ethics 1995;21:298304CrossRefGoogle ScholarPubMed) raised the same question in the 1990s, when researchers at Edinburgh University were working on transplanting the ovaries of an aborted fetus into an infertile woman.