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Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation

Published online by Cambridge University Press:  29 July 2009

Donald S. Rubenstein ,
David C. Thomasma ,
Eric A. Schon  and
Michael J. Zinaman
Donald S. Rubenstein
Affiliation:
Cardiology Fellow at Loyola University of Chicago and is a Clinical Investigator of the American Board of Internal Medicine
David C. Thomasma
Affiliation:
Fr. Michael I. English S.J. Professor of Medical Ethics and Director of the Medical Humanities Program at Loyola University Chicago Medical Center and the Director of the International Bioethics Institute.
Eric A. Schon
Affiliation:
An Associate Professor of Genetics and Development (In Neurology) at Columbia University College of Physicians and Surgeons, New York
Michael J. Zinaman
Affiliation:
An Associate Professor and division Director of Reproductive Endocrinology and Infertility at Loyola University of Chicago.
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Extract

The combination of genuine ethical concerns and fear of learning to use germ-line therapy for human disease must now be confronted. Until now, no established techniques were available to perform this treatment on a human. Through an integration of several fields of science and medicine, we have developed a nine step protocol at the germ-line level for the curative treatment of a genetic disease. Our purpose in this paper is to provide the first method to apply germ-line therapy to treat those not yet born, who are destined to have a life threatening, or a severely debilitating genetic disease. We hope this proposal will initiate the process of a thorough analysis from both the scientific and ethical communities. As such, this proposal can be useful for official groups studying the advantages and disadvantages of germ-line therapy.

Type
Special Section: Designs on Life: Choice, Control, and Responsibility in Genetic Manipulation
Information
Cambridge Quarterly of Healthcare Ethics , Volume 4 , Issue 3 , Summer 1995 , pp. 316 - 339
Copyright
Copyright © Cambridge University Press 1995

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References

Notes

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